Needle core vs open biopsy for diagnosis of intermediate- and high-risk neuroblastoma in children

Hassan, Saif F.; Mathur, Shawn; Magliaro, Thomas J.; Larimer, Emily L.; Ferrell, L. B.; Vasudevan, Sanjeev A.; Patterson, Danielle; Louis, Chrystal U.; Russell, Heidi V.; Nuchtern, Jed G.; Kim, Eugene

doi:10.1016/j.jpedsurg.2012.03.040

Cited by 54 publications

(54 citation statements)

References 18 publications

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“…3,[6][7][8][9]11 Of the 4 cases, we missed on the first biopsy, 3 were secondary to radiologist error in choosing the best sonographic window to sample the suspected site, and soon after a second US-guided biopsy corrected the technical error. 3,[6][7][8][9]11 Of the 4 cases, we missed on the first biopsy, 3 were secondary to radiologist error in choosing the best sonographic window to sample the suspected site, and soon after a second US-guided biopsy corrected the technical error.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-guided Core Biopsy as the Primary Tool for Tissue Diagnosis in Pediatric Oncology

Ilivitzki

Abu-Gazala

Arkovitz

et al. 2014

Journal of Pediatric Hematology/Oncology

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Section: Discussionmentioning

confidence: 99%

Ultrasound-guided Core Biopsy as the Primary Tool for Tissue Diagnosis in Pediatric Oncology

Ilivitzki

Abu-Gazala

Arkovitz

et al. 2014

Journal of Pediatric Hematology/Oncology

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“…Several reports have demonstrated comparable accuracy between PCNB and IB, while others challenge the full diagnostic yield of PCNB. [7][8][9][10][11][12][13] Significant variability exists regarding which patients may benefit from PCNB, and standard surgical techniques have not been defined for PCNB. Several small studies have demonstrated lower or similar complication rates, but detailed procedural and postoperative outcomes are lacking.…”

Section: Conclusion: Pcnb Is a Less Invasive Alternative To Open Biomentioning

confidence: 99%

“…There is conflicting data regarding the efficacy of PCNB for cytogenetic analysis, relying primarily on single‐institutional data. Several reports have demonstrated comparable accuracy between PCNB and IB, while others challenge the full diagnostic yield of PCNB . Significant variability exists regarding which patients may benefit from PCNB, and standard surgical techniques have not been defined for PCNB.…”

Section: Introductionmentioning

confidence: 99%

“…utilization of PCNB for diagnosis and pathologic characterization of neuroblastoma and other pediatric solid tumors has increased in recent years 5,9. Several reports have found similar efficacy in diagnosis rate between percutaneous and open biopsy methods, while others have reported decreased diagnostic yield with PCNB 7,8,10,11. The INRG classification system outlines pretreatment risk groups to stratify patients based on probability of disease progression and recurrence.This classification system requires age, histologic factors, and biologic and genetic characterization (MYCN amplification, DNA ploidy, and loss of heterozygosity at 11q) 1,15.…”

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confidence: 99%

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Optimization of percutaneous biopsy for diagnosis and pretreatment risk assessment of neuroblastoma

Overman

Kartal

Cunningham

et al. 2020

Pediatric Blood & Cancer

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Background Image‐guided percutaneous core needle biopsy (PCNB) is increasingly utilized to diagnose solid tumors. The objective of this study is to determine whether PCNB is adequate for modern biologic characterization of neuroblastoma. Procedure A multi‐institutional retrospective study was performed by the Pediatric Surgical Oncology Research Collaborative on children with neuroblastoma at 12 institutions over a 3‐year period. Data collected included demographics, clinical details, biopsy technique, complications, and adequacy of biopsies for cytogenetic markers utilized by the Children's Oncology Group for risk stratification. Results A total of 243 children were identified with a diagnosis of neuroblastoma: 79 (32.5%) tumor excision at diagnosis, 94 (38.7%) open incisional biopsy (IB), and 70 (28.8%) PCNB. Compared to IB, there was no significant difference in ability to accurately obtain a primary diagnosis by PCNB (95.7% vs 98.9%, P = .314) or determine MYCN copy number (92.4% vs 97.8%, P = .111). The yield for loss of heterozygosity and tumor ploidy was lower with PCNB versus IB (56.1% vs 90.9%, P < .05; and 58.0% vs. 88.5%, P < .05). Complications did not differ between groups (2.9 % vs 3.3%, P = 1.000), though the PCNB group had fewer blood transfusions and lower opioid usage. Efficacy of PCNB was improved for loss of heterozygosity when a pediatric pathologist evaluated the fresh specimen for adequacy. Conclusions PCNB is a less invasive alternative to open biopsy for primary diagnosis and MYCN oncogene status in patients with neuroblastoma. Our data suggest that PCNB could be optimized for complete genetic analysis by standardized protocols and real‐time pathology assessment of specimen quality.

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“…Criteria for identifying patients qualifying for minimal invasive surgery have been published elsewhere [53]. Fine needle and core needle biopsies are not recommended since they yield tumor tissue limited in quantity and quality, which may be insufficient for state-of-the-art pathology and molecular analyses [71,80]. Delayed tumor resection should be considered for observation patients who have non-progressing residual tumors and have reached the end of the 2 nd year of life (patients diagnosed at < 1 year of age) or have been under observation for 1 year (patients diagnoses at ≥ 1 year of age) if the risk of surgery appears low.…”

Section: Surgerymentioning

confidence: 99%

2017 GPOH Guidelines for Diagnosis and Treatment of Patients with Neuroblastic Tumors

et al. 2017

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The clinical course of neuroblastoma is more heterogeneous than any other malignant disease. Most low-risk patients experience regression after limited or even no chemotherapy. However, more than half of high-risk patients die from disease despite intensive multimodal treatment. Precise patient characterization at diagnosis is key for risk-adapted treatment. The guidelines presented here incorporate results from national and international clinical trials to produce recommendations for diagnosing and treating neuroblastoma patients in German hospitals outside of clinical trials.

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Needle core vs open biopsy for diagnosis of intermediate- and high-risk neuroblastoma in children

Cited by 54 publications

References 18 publications

Ultrasound-guided Core Biopsy as the Primary Tool for Tissue Diagnosis in Pediatric Oncology

Ultrasound-guided Core Biopsy as the Primary Tool for Tissue Diagnosis in Pediatric Oncology

Optimization of percutaneous biopsy for diagnosis and pretreatment risk assessment of neuroblastoma

2017 GPOH Guidelines for Diagnosis and Treatment of Patients with Neuroblastic Tumors

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