Needle-based confocal laser endomicroscopy in the diagnosis of peripheral pulmonary nodule: a preliminary report

Su, Zhu‐Quan; Zhong, Chang-Hao; Li, Shiyue; Chen, Xiaobo; Chen, Yu; Tang, Chunli

doi:10.21037/jtd.2017.06.10

Cited by 13 publications

(17 citation statements)

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“…Two optical imaging techniques currently used for needle-based optical biopsies are confocal laser endomicroscopy (CLE) and optical coherence tomography (OCT) [ 14 - 17 ]. CLE and OCT differ in background technology and image geometry and, therefore, show different images of the scanned tissue, see Figures 1 and 2 .…”

Section: Introductionmentioning

confidence: 99%

Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A)

et al. 2018

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BackgroundFocal therapy for prostate cancer has been proposed as an alternative treatment to whole-gland therapies in selected men to diminish side effects in localized prostate cancer. As nowadays imaging cannot offer complete prostate cancer disease characterization, multicore systematic biopsies are recommended (transrectal or transperineal). Optical imaging techniques such as confocal laser endomicroscopy and optical coherence tomography allow in vivo, high-resolution imaging. Moreover, they can provide real-time visualization and analysis of tissue and have the potential to offer additive diagnostic information.ObjectiveThis study has 2 separate primary objectives. The first is to assess the technical feasibility and safety of in vivo focal imaging with confocal laser endomicroscopy and optical coherence tomography. The second is to identify and define characteristics of prostate cancer and normal prostate tissue in confocal laser endomicroscopy and optical coherence tomography imaging by comparing these images with the corresponding histopathology.MethodsIn this prospective, in vivo feasibility study, needle-based confocal laser endomicroscopy and optical coherence tomography imaging will be performed before transperineal template mapping biopsy or radical prostatectomy. First, confocal laser endomicroscopy and optical coherence tomography will be performed in 4 patients (2 for each imaging modality) undergoing transperineal template mapping biopsy to assess the feasibility and safety of confocal laser endomicroscopy and optical coherence tomography. If proven to be safe and feasible, confocal laser endomicroscopy and optical coherence tomography will be performed in 10 patients (5 for each imaging modality) undergoing radical prostatectomy. Confocal laser endomicroscopy and optical coherence tomography images will be analyzed by independent, blinded observers. Confocal laser endomicroscopy– and optical coherence tomography–based qualitative and quantitative characteristics and histopathology will be compared. The study complies with the IDEAL (Idea, Development, Exploration, Assessment, Long-term study) stage 2a recommendations.ResultsAt present, the study is enrolling patients and results and outcomes are expected in 2019.ConclusionsConfocal laser endomicroscopy and optical coherence tomography are promising optical imaging techniques that can visualize and analyze tissue structure, possible tumor grade, and architecture in real time. They can potentially provide real-time, high-resolution microscopic imaging and tissue characteristics of prostate cancer in conjunction with magnetic resonance imaging or transrectal ultrasound fusion-guided biopsy procedures. This study will provide insight into the feasibility and tissue-specific characteristics of confocal laser endomicroscopy and optical coherence tomography for real-time optical analysis of prostate cancer.Trial RegistrationClinicalTrials.gov NCT03253458; https://clinicaltrials.gov/ct2/show/NCT03253458 (Archived by WebCite at http://www.webcitation.org...

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Section: Introductionmentioning

confidence: 99%

Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A)

et al. 2018

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“…It provides an in vivo histopathological assessment during the endoscopic process, as well as allowing for real-time image acquisition during the EUS process. However, for pneumological lesions, it is a rather new technique [4][5][6].…”

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confidence: 99%

“…With adequate training, the operator should be able to identify the areas of interest for sampling, thus improving the diagnostic yield. CLE has also been found to be useful for the exploration of alveolar structures and mucosal tissue in vivo [4][5][6].…”

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A journey to the centre of the mediastinal lymph nodes

Amat

Sapia

2019

Eur Respir J

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“…Two optical imaging techniques currently used for needle-based optical biopsies are confocal laser endomicroscopy (CLE) and optical coherence tomography (OCT) [14][15][16][17]. CLE and OCT differ in background technology and image geometry and, therefore, show different images of the scanned tissue, see figure 1 and figure 2.…”

mentioning

confidence: 99%

Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A) (Preprint)

Swaan¹,

Mannaerts²,

Scheltema³

et al. 2018

Preprint

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BackgroundFocal therapy for prostate cancer (PCa) has been proposed as an alternative treatment to wholegland therapies in selected men to diminish side effects in localized prostate cancer. Since existing PCa imaging cannot offer complete PCa disease characterization, multi-core systematic biopsies are recommended (transrectal or transperineal). Optical imaging techniques such as confocal laser endomicroscopy (CLE) and optical coherence tomography (OCT) allow in-vivo, high-resolution imaging, and can provide real-time visualization and analysis of tissue and have the potential to offer additive diagnostic information. ObjectiveThis study has two seperate primary objectives. The first is to assess the technical feasibility and safety of in-vivo focal imaging with CLE and OCT. The second is to identify and define characteristics of PCa and normal prostate tissue in CLE and OCT imaging by comparing these images with the corresponding histopathology.

show abstract

Needle-based confocal laser endomicroscopy in the diagnosis of peripheral pulmonary nodule: a preliminary report

Cited by 13 publications

References 11 publications

Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A)

Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A)

A journey to the centre of the mediastinal lymph nodes

Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A) (Preprint)

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