Need for establishing integrated programs to monitor endocrine active compounds

Segner, Helmut

doi:10.1351/pac200375112435

Cited by 6 publications

(1 citation statement)

References 51 publications

(69 reference statements)

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“…Some studies reported reasonable to good correlation between estrogenic levels in surface water and the VTG response [24] or between effluent loading of the river and VTG induction in exposed fish [25,26], but a number of other studies found no clear relationship between estrogenic exposure and the VTG biomarker response [27–29]. Such discrepancies point to the need to develop further the monitoring strategies for assessment of estrogenic contamination of aquatic environments [30].…”

Section: Introductionmentioning

confidence: 99%

Assessment of estrogenic exposure in brown trout (Salmo trutta) in a Swiss midland river: Integrated analysis of passive samplers, wild and caged fish, and vitellogenin mRNA and protein

Burki

Vermeirssen

Körner

et al. 2006

Enviro Toxic and Chemistry

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This field study examined the vitellogenin (VTG) biomarker response under conditions of low and fluctuating activities of environmental estrogenicity. The present study was performed on immature brown trout (Salmo trutta) exposed to the small river Luetzelmurg, which is located in the prealpine Swiss midland region and receives effluents from a single sewage treatment plant (STP). To understand better factors influencing the relationship between estrogenic exposure and VTG induction, we compared VTG levels in caged (stationary) and feral (free-ranging) fish, VTG levels in fish from up- and downstream of the STP, and two different methods for quantifying VTG (enzyme-linked immunosorbent assay vs real-time reverse transcription-polymerase chain reaction), and we used passive samplers (polar organic chemical integrative sampler [POCIS]) to integrate the variable, bioaccumulative estrogenic load in the river water over time. The POCIS from the downstream site contained approximately 20-fold higher levels of bioassay-derived estrogen equivalents than the POCIS from the upstream site. In feral fish, this site difference in estrogenic exposure was reflected in VTG protein levels but not in VTG mRNA. In contrast, in caged fish, the site difference was evident only for VTG mRNA but not for VTG protein. Thus, the outcome of VTG biomarker measurements varied with the analytical detection method (protein vs mRNA) and with the exposure modus (caged vs feral). Our findings suggest that for environmental situations with low and variable estrogenic contamination, a multiple-assessment approach may be necessary for the assessment of estrogenic exposure in fish.

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Section: Introductionmentioning

confidence: 99%

Assessment of estrogenic exposure in brown trout (Salmo trutta) in a Swiss midland river: Integrated analysis of passive samplers, wild and caged fish, and vitellogenin mRNA and protein

Burki

Vermeirssen

Körner

et al. 2006

Enviro Toxic and Chemistry

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Developmental, Reproductive, and Demographic Alterations in Aquatic Wildlife: Establishing Causality between Exposure to Endocrine-active Compounds (EACs) and Effects

Segner

2005

Acta hydrochim. hydrobiol.

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Switzerland Compounds (EACs) and Effects*This brief overview discusses the difficulty of demonstrating causal associations between exposure to endocrine active compounds (EACs) and the occurrence of developmental, reproductive, or demographic disturbances in aquatic wildlife. While for biological responses at the suborganism level correlational or causal evidence of an EAC etiology has been established in a number of cases, well proven examples of ecological consequences of endocrine disruption are rather few in number. The attribution of causality is complicated due to (i) lack of data on EAC exposure and bioaccumulation, (ii) lack of specific biomarkers and endpoints, together with insufficient knowledge on the mechanisms and conditions by which EAC-induced disruption of endocrine functions translates into impaired organism development and reproduction, and (iii) insufficient understanding of the importance of species diversity in endocrine physiology and life histories for the consequences of endocrine disruption. Future research should address these gaps in our understanding of EAC exposure and effects, but additionally needs to pay more attention (i) to ecological determinants influencing the population-level consequences of the endocrine disruption of developmental and reproductive functions, and (ii) to the use of epidemiological principles and approaches. Veränderungen in der aquatischen

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Ecotoxicology – How to Assess the Impact of Toxicants in a Multi-Factorial Environment?

Segner

NATO Science for Peace and Security Series C: Environmental Security

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Need for establishing integrated programs to monitor endocrine active compounds

Cited by 6 publications

References 51 publications

Assessment of estrogenic exposure in brown trout (Salmo trutta) in a Swiss midland river: Integrated analysis of passive samplers, wild and caged fish, and vitellogenin mRNA and protein

Assessment of estrogenic exposure in brown trout (Salmo trutta) in a Swiss midland river: Integrated analysis of passive samplers, wild and caged fish, and vitellogenin mRNA and protein

Developmental, Reproductive, and Demographic Alterations in Aquatic Wildlife: Establishing Causality between Exposure to Endocrine-active Compounds (EACs) and Effects

Ecotoxicology – How to Assess the Impact of Toxicants in a Multi-Factorial Environment?

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