Nedocromil sodium and levocabastine reduce the symptoms of conjunctival allergen challenge by different mechanisms

Ahluwalia, Poonam; Anderson, David F.; Wilson, Susan J.; McGill, James; Church, Martin K.

doi:10.1067/mai.2001.117591

Cited by 36 publications

(15 citation statements)

References 36 publications

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“…Specific pharmacological intervention studies in which mast cell specific anti-allergic drugs, such as anti-histaminic and mast cell stabilising drugs are used [61], could also help to unravel the mechanisms underlying this chronic disease.…”

Section: Discussionmentioning

confidence: 99%

Mast cells are involved in inflammatory reactions during Complex Regional Pain Syndrome type 1

Huygen¹,

Ramdhani²,

et al. 2004

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Section: Discussionmentioning

confidence: 99%

Mast cells are involved in inflammatory reactions during Complex Regional Pain Syndrome type 1

Huygen¹,

Ramdhani²,

et al. 2004

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“…In addition to the increase in mast cells within the conjunctiva, the number of mast cells expressing IL-4 message is increased threefold in seasonal allergic conjunctivitis [116]. Further, use of a mast cell stabilizer (nedocromil sodium) reduces the amount of histamine and PGD 2 by more than 70% after challenge, thereby supporting a major role for mast cells in allergic conjunctivitis [117].…”

Section: Allergic Eye Diseasementioning

confidence: 95%

The mast cell and allergic diseases: role in pathogenesis and implications for therapy

Brown

Wilson

Metcalfe

2007

Clin Experimental Allergy

239

184

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SummaryMast cells have long been recognized for their role in the genesis of allergic inflammation; and more recently for their participation in innate and acquired immune responses. Mast cells reside within tissues including the skin and mucosal membranes, which interface with the external environment; as well as being found within vascularized tissues next to nerves, blood vessels and glandular structures. Mast cells have the capability of reacting both within minutes and over hours to specific stimuli, with local and systemic effects. Mast cells express the high affinity IgE receptor (FceRI) and upon aggregation of FceRI by allergen-specific IgE, mast cells release and generate biologically active preformed and newly synthesized mediators which are involved in many aspects of allergic inflammation. While mast cells have been well documented to be essential for acute allergic reactions, more recently the importance of mast cells in reacting through pattern recognition receptors in innate immune responses has become recognized. Moreover, as our molecular understanding of the mast cell has evolved, novel targets for modulation have been identified with promising therapeutic potential.

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“…Cetirizine [18] and fexofenadine [19] also demonstrate antagonism of ICAM-1. Topical antihistamine levocabastine [20,21] blocks H1 receptors and ICAM-1. Mast cell stabilizers such as cromolyn sodium [22], nedocromil sodium [23], lodoxamide [24] and pemirolast [25] all target mast cells to prevent degranulation.…”

Section: Clinically Available Agentsmentioning

confidence: 99%

Pharmacology of ocular allergy

Schultz

2006

Current Opinion in Allergy &Amp; Clinical Immunology

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Important pharmacologic properties of targets have been revealed. First, histamine is more specifically antagonized by second generation antihistamines. Second, newly formed mediators and downstream responders (prostaglandins, leukotrienes, interleukins, intercellular adhesion molecule 1, tumor necrosis factor, vascular cell adhesion molecule, eosinophils and neutrophils) are more selectively antagonized by dual/multiple-action agents.

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Nedocromil sodium and levocabastine reduce the symptoms of conjunctival allergen challenge by different mechanisms

Cited by 36 publications

References 36 publications

Mast cells are involved in inflammatory reactions during Complex Regional Pain Syndrome type 1

Mast cells are involved in inflammatory reactions during Complex Regional Pain Syndrome type 1

The mast cell and allergic diseases: role in pathogenesis and implications for therapy

Pharmacology of ocular allergy

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