Neddylation orchestrates the complex transcriptional and posttranscriptional program that drives Schwann cell myelination
Paula Ayuso-García,
Alejandro Sánchez-Rueda,
Sergio Velasco-Avilés
et al.
Abstract:Myelination is essential for neuronal function and health. In peripheral nerves, >100 causative mutations have been identified that cause Charcot-Marie-Tooth disease, a disorder that can affect myelin sheaths. Among these, a number of mutations are related to essential targets of the posttranslational modification neddylation, although how these lead to myelin defects is unclear. Here, we demonstrate that inhibiting neddylation leads to a notable absence of peripheral myelin and axonal loss both in developi… Show more
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