2021
DOI: 10.1164/rccm.202101-0007ed
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NEDD9, a Hypoxia-upregulated Mediator for Pathogenic Platelet–Endothelial Cell Interaction in Pulmonary Hypertension

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Cited by 8 publications
(5 citation statements)
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“…43 C-C motif chemokine ligand 2 (CCL2) was observed to be associated with the risk of myocardial infarction. 44 Genes include secreted phosphoprotein 1 (SPP1), 45 75 transforming growth factor beta receptor 1 (TGFBR1), 76 HSP90AB1, 77 pleckstrin homology domain containing A7 (PLEKHA7), 78 angiotensin II receptor-associated protein (AGTRAP), 79 solute carrier family 16 member 9 (SLC16A9), 80 acyl-CoA dehydrogenase short/branched chain (ACADSB), 81 inositol monophosphatase 1 (IMPA1), 82 CD300 molecule-like family member g (CD300LG), 83 cold inducible RNA-binding protein (CIRBP), 84 PIK3R1, 85 YEATS4, 86 ubiquitin specific peptidase 2 (USP2), 87 neural precursor cell expressed, developmentally downregulated 9 (NEDD9), 88 coiled-coil-helix-coiled-coil-helix domain containing 5 (CHCHD5), 89 and endoplasmic reticulum aminopeptidase 1 (ERAP1) 90 might crucially contribute to the development of hypertension. Genes include heat shock protein family B (small) member 1 (HSPB1), 91 crystallin alpha B (CRYAB), 92 annexin A5 (ANXA5), 93 C-C motif chemokine receptor 2 (CCR2), 94 regulator of G protein signaling 4 (RGS4), 95 TNF receptor superfamily member 1A (TNFRSF1A), 96 X-boxbinding protein 1 (XBP1), 97 NK2 homeobox 5 (NKX2-5), 98 neuraminidase 1 (NEU1), 99 glutathione S-transferase pi 1 (GSTP1), 100 catechol-O-methyltransferase (COMT), 101 LIM domain kinase 1 (LIMK1), 102 calcium/calmodulindependent protein kinase kinase 1 (CAMKK1), 103 CD276 molecule (CD276), 104 SMARCA4, 105 adenosine A2b receptor (ADORA2B), 106 acyl-CoA thioesterase 1 (ACOT1), 107 regucalcin (RGN), 108 inorganic pyrophosphatase 2 (PPA2), 109 KAT2B, 110 pyruvate dehydrogenase kinase 1 (PDK1), 111 citrate synthase (CS), 112 fibroblast growth factor 12 (FGF12), 113 aquaporin 4 (AQP4), 114 leiomodin 2 (LMOD2), 115 selenium-binding protein 1 (SELENBP1), 116 myoglobin (MB), 117 S100 calcium-binding protein A1 (S100A1), 118 ryanodine receptor 2 (RYR2), 119 glypican 5 (GPC5), 120 jumonji and AT-rich interaction domain containing 2 (JARID2), 121 EGFR, 122 FUN14 domain containing 1 (FUNDC1), 123 sphingosine-1-phosphate receptor 1 (S1PR1), 124 endothelial PAS domain protein 1 (EPAS1), 125 and oxysterol-binding protein-like 11 (OSBPL11) 126 played a critical role in HF.…”
Section: Discussionmentioning
confidence: 99%
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“…43 C-C motif chemokine ligand 2 (CCL2) was observed to be associated with the risk of myocardial infarction. 44 Genes include secreted phosphoprotein 1 (SPP1), 45 75 transforming growth factor beta receptor 1 (TGFBR1), 76 HSP90AB1, 77 pleckstrin homology domain containing A7 (PLEKHA7), 78 angiotensin II receptor-associated protein (AGTRAP), 79 solute carrier family 16 member 9 (SLC16A9), 80 acyl-CoA dehydrogenase short/branched chain (ACADSB), 81 inositol monophosphatase 1 (IMPA1), 82 CD300 molecule-like family member g (CD300LG), 83 cold inducible RNA-binding protein (CIRBP), 84 PIK3R1, 85 YEATS4, 86 ubiquitin specific peptidase 2 (USP2), 87 neural precursor cell expressed, developmentally downregulated 9 (NEDD9), 88 coiled-coil-helix-coiled-coil-helix domain containing 5 (CHCHD5), 89 and endoplasmic reticulum aminopeptidase 1 (ERAP1) 90 might crucially contribute to the development of hypertension. Genes include heat shock protein family B (small) member 1 (HSPB1), 91 crystallin alpha B (CRYAB), 92 annexin A5 (ANXA5), 93 C-C motif chemokine receptor 2 (CCR2), 94 regulator of G protein signaling 4 (RGS4), 95 TNF receptor superfamily member 1A (TNFRSF1A), 96 X-boxbinding protein 1 (XBP1), 97 NK2 homeobox 5 (NKX2-5), 98 neuraminidase 1 (NEU1), 99 glutathione S-transferase pi 1 (GSTP1), 100 catechol-O-methyltransferase (COMT), 101 LIM domain kinase 1 (LIMK1), 102 calcium/calmodulindependent protein kinase kinase 1 (CAMKK1), 103 CD276 molecule (CD276), 104 SMARCA4, 105 adenosine A2b receptor (ADORA2B), 106 acyl-CoA thioesterase 1 (ACOT1), 107 regucalcin (RGN), 108 inorganic pyrophosphatase 2 (PPA2), 109 KAT2B, 110 pyruvate dehydrogenase kinase 1 (PDK1), 111 citrate synthase (CS), 112 fibroblast growth factor 12 (FGF12), 113 aquaporin 4 (AQP4), 114 leiomodin 2 (LMOD2), 115 selenium-binding protein 1 (SELENBP1), 116 myoglobin (MB), 117 S100 calcium-binding protein A1 (S100A1), 118 ryanodine receptor 2 (RYR2), 119 glypican 5 (GPC5), 120 jumonji and AT-rich interaction domain containing 2 (JARID2), 121 EGFR, 122 FUN14 domain containing 1 (FUNDC1), 123 sphingosine-1-phosphate receptor 1 (S1PR1), 124 endothelial PAS domain protein 1 (EPAS1), 125 and oxysterol-binding protein-like 11 (OSBPL11) 126 played a critical role in HF.…”
Section: Discussionmentioning
confidence: 99%
“…Han et al , 60 Yamada et al , 61 Wang et al , 62 García-Manzanares et al , 63 Raitoharju et al , 64 King et al , 65 Hirokawa et al , 66 Kahali et al , 67 Kuhn et al 68 , and Sun et al 69 found that expression of 24-dehydrocholesterol reductase (DHCR24), syntaxin-binding protein 2 (STXBP2), C-type lectin domain containing 5A (CLEC5A), XPO1, ADAM metallopeptidase domain 8 (ADAM8), interferon regulatory factor 3 (IRF3), DOT1-like histone lysine methyltransferase (DOT1 L), protein phosphatase 1 regulatory subunit 3B (PPP1R3B), IFIT3, and proproteinconvertasesubtilisin/kexin type 6 (PCSK6) could induce myocardial infarction. Altered expression of genes includes cytochrome P450 family 1 subfamily B member 1 (CYP1B1), 70 solute carrier family 7 member 1 (SLC7A1), 71 MYH9, 72 linker for activation of T cells family member 2 (LAT2), 73 FXYD domain containing ion transport regulator 5 (FXYD5), 74 calcium/calmodulin-dependent protein kinase I (CAMK1), 75 transforming growth factor beta receptor 1 (TGFBR1), 76 HSP90AB1, 77 pleckstrin homology domain containing A7 (PLEKHA7), 78 angiotensin II receptor-associated protein (AGTRAP), 79 solute carrier family 16 member 9 (SLC16A9), 80 acyl-CoA dehydrogenase short/branched chain (ACADSB), 81 inositol monophosphatase 1 (IMPA1), 82 CD300 molecule-like family member g (CD300LG), 83 cold inducible RNA-binding protein (CIRBP), 84 PIK3R1, 85 YEATS4, 86 ubiquitin specific peptidase 2 (USP2), 87 neural precursor cell expressed, developmentally downregulated 9 (NEDD9), 88 coiled-coil-helix-coiled-coil-helix domain containing 5 (CHCHD5), 89 and endoplasmic reticulum aminopeptidase 1 (ERAP1) 90 might crucially contribute to the development of hypertension. Genes include heat shock protein family B (small) member 1 (HSPB1), 91 crystallin alpha B (CRYAB), 92 annexin A5 (ANXA5), 93 C-C motif chemokine receptor 2 (CCR2), 94 regulator of G protein signaling 4 (RGS4), 95 TNF receptor superfamily member 1A (TNFRSF1A),…”
Section: Discussionmentioning
confidence: 99%
“…Recent studies found that KCP (kielin cysteine rich BMP regulator) [117], NOG (noggin) [118], COL6A3 [119], BTG2 [120], RPS6 [121], KLF15 [122], KLF3 [123], ZFP36 [124], ETV5 [125], TLE3 [126], NNMT (nicotinamide Nmethyltransferase) [127], WDTC1 [128], ZFHX3 [129], SIAH2 [130], MBOAT7 [131], RUNX1T1 [132], MAPK4 [133], KLF9 [134], SELENBP1 [135], HELZ2 [136], ELK1 [137], SERTAD2 [138], CRTC3 [139], ABCB11 [140], TACR1 [141], SLC22A11 [142], PER3 [143], P2RX5 [144], MFAP5 [145], FGL1 [146], OLFM4 [147], NTN1 [148], ESR1 [149], ABCB1 [150] [248] are expressed in cardiovascular disease, but these genes might be novel target for T1DM. MAOB (monoamine oxidase B) [249], VEGFC (vascular endothelial growth factor C) [250], DBP (D-box binding PAR bZIP transcription factor) [251], MYADM (myeloid associated differentiation marker) [252], NES (nestin) [253], SMURF1 [254], EDNRB (endothelin receptor type B) [255], MUC6 [256], TOR2A [257], TNKS (tankyrase) [258], NEDD9 [259], ASIC1 ...…”
Section: Discussionmentioning
confidence: 99%
“…A previous study reported that FAP (fibroblast activation protein alpha) [205], EYA4 [206], BCL9 [207], IRF2BP2 [208], EGR3 [209], GADD45B [210], DMD (dystrophin) [211], LSR (lipolysis stimulated lipoprotein receptor) [212], DLL4 [213], SUN2 [214], SOS1 [215], PIK3CA [216], GAMT (guanidinoacetate N-methyltransferase) [217], RBM47 [218], HSP90AA1 [219], GAB1 [220], S1PR1 [221], EDNRB (endothelin receptor type B) [222], NFKBIA (NFKB inhibitor alpha) [223], GJA1 [224], GADD45G [225], PHLDA1 [226], CMPK2 [227], FIGN (fidgetin, microtubule severing factor) [228], KCNJ2 [229], ABCC9 [230], DIRAS3 [231], EPHX1 [232], RAB4A [233], UBIAD1 [234], CASQ2 [235], TTN (titin) [236], KCNH1 [237], JPH2 [238], OXGR1 [239], UCHL1 [240], SERPINA3 [241], MMP28 [242], ADAMTS2 [243], P2RY1 [244], CSF2RA [245], MYO1F [246], SELPLG (selectin P ligand) [247] and SAMHD1 [248] are expressed in cardiovascular disease, but these genes might be novel target for T1DM. MAOB (monoamine oxidase B) [249], VEGFC (vascular endothelial growth factor C) [250], DBP (D-box binding PAR bZIP transcription factor) [251], MYADM (myeloid associated differentiation marker) [252], NES (nestin) [253], SMURF1 [254], EDNRB (endothelin receptor type B) [255], MUC6 [256], TOR2A [257], TNKS (tankyrase) [258], NEDD9 [259], ASIC1 [260], ADAMTS8 [261], DYSF (dysferlin) [262], SLC26A9 [263], SLC45A3 [264] and KCNQ2 [265] contributes to the progression of hypertension, but these genes might be novel target for T1DM. Yang et al [266], Zhang et al [267] and Wang et al [268] demonstrated that SYVN1, BTG1 and CFB (complement factor B) were associated with diabetic retinopathy, but these genes mi...…”
Section: Discussionmentioning
confidence: 99%
“…Kiczak et al [44] found that TIMP1 was highly expressed in the HF. GO [76], SLC16A9 [77], ACADSB (acyl-CoA dehydrogenase short/branched chain) [78], IMPA1 [79], CD300LG [80], CIRBP (cold inducible RNA binding protein) [81], PIK3R1 [82], YEATS4 [83], USP2 [84], NEDD9 [85], CHCHD5 [86] and ERAP1 [87] promotes hypertension. HSPB1 [88], CRYAB (crystallin alpha B) [89], ANXA5 [90], CCR2 [91], RGS4 [92], TNFRSF1A [93], XBP1 [94], NKX2-5 [95], NEU1 [96], GSTP1 [97], COMT (catechol-O-methyltransferase) [98], LIMK1 [99], CAMKK1 [100], CD276 [101], SMARCA4 [102], ADORA2B [103], ACOT1 [104], RGN (regucalcin) [105], PPA2 [106], KAT2B [107], PDK1 [108], CS (citrate synthase)…”
Section: Discussionmentioning
confidence: 99%