Necrotizing Soft Tissue Infections: Delayed Surgical Treatment Is Associated With Increased Number of Surgical Debridements and Morbidity

Kobayashi, Leslie; Konstantinidis, Agathoklis; Shackelford, Stacy; Chan, Linda S.; Talving, Peep; Inaba, Kenji; Δημητριάδης, Δημήτριος

doi:10.1097/ta.0b013e31820db8fd

Cited by 102 publications

(95 citation statements)

References 14 publications

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“…Seems prudent that, whenever possible, source control should be attempted as soon as foci is detected. A delayed first surgical intervention (more than 12 hours) is associated with higher mortality (14), however in a recent report (15) an early intervention (less than 6 hours from diagnosis) was associated with shorter ICU and hospital length of stay but no statistical differences in mortality were founded between early and late surgery. Antibiotics should be given as any septic shock patient in the first 6 hours, and administration of clindamycin is highly recommended in order to inhibit exotoxin production of Gram-positive bacteria.…”

Section: Soft Tissue and Skin Infectionsmentioning

confidence: 82%

Current understanding in source control management in septic shock patients: a review

Lagunes¹,

Encina²,

Ramirez-Estrada³

2016

Ann. Transl. Med.

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Section: Soft Tissue and Skin Infectionsmentioning

confidence: 82%

Current understanding in source control management in septic shock patients: a review

Lagunes¹,

Encina²,

Ramirez-Estrada³

2016

Ann. Transl. Med.

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“…Delay of more than 12 hours to initial debridement has been associated with increased number of surgical debridement's and a higher incidence of septic shock and acute renal failure [13] .…”

Section: Table1: Demographic Data Of Patientsmentioning

confidence: 99%

Necrotizing Soft Tissue Infections

Goud¹

2017

jmscr

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“…Some of the risk factors associated with NSTIs include Type 2 Diabetes Mellitus (DM2), obesity, smoking, immobility, alcohol abuse, cirrhosis of the liver, HIV, intravenous drug abuse (IVDA), and malnutrition [9,10]. Treatment typically includes early broad-spectrum intravenous (IV) antibiotics, fluid resuscitation, vasopressor support, and extensive debridement [1,[11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Clinical comparison of fournier’s gangrene to other necrotizing soft tissue infections

Puckett¹,

Fisher²

2015

Res J Infect Dis

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Background: The purpose of this study was to review key differences between necrotizing soft tissue infections (NSTI) and Fournier's Gangrene (FG) in demographics, comorbidities, laboratory findings, cost, and clinical course. Methods:The burn registry of a Level 1 trauma and burn center in Lubbock, Texas was used to identify and retrospectively review medical records of patients with NSTIs and FG from 2003 to 2012. Bivariate analysis on the FG subgroup was performed and compared to all other NSTI using Fisher's exact test for proportions and Student's t-test to compare continuous variables with equal variance assumed. A p<0.05 was considered to be significant. Results: We found that 133 patients met inclusion criteria. Analysis of data revealed that FG had longer length of hospital stay (p=0.02) and an increased number of operations performed (p=0.01) than other NSTIs. There was also a higher association with diabetes in FG (p=0.03) and polymicrobial infections (p=0.01). Intravenous drug abuse was found to be more associated with NSTIs compared to FG (p=0.03). Conclusion: Our study showed that FG patients have longer length of hospital stay, lower hemoglobin levels, and increased number of operations. NSTIs were more likely to be associated with intravenous drug abuse. There is no difference in rates of mortality between the two groups.

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Necrotizing Soft Tissue Infections: Delayed Surgical Treatment Is Associated With Increased Number of Surgical Debridements and Morbidity

Abstract: In patients with NSTI, a delay of surgical treatment of >12 hours is associated with an increased number of surgical debridements and higher incidence of septic shock and acute renal failure.

Cited by 102 publications

References 14 publications

Current understanding in source control management in septic shock patients: a review

Current understanding in source control management in septic shock patients: a review

Necrotizing Soft Tissue Infections

Clinical comparison of fournier’s gangrene to other necrotizing soft tissue infections

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