Necrotizing funisitis: Clinical significance and association with chronic lung disease in premature infants

Matsuda, Tadashi; Nakajima, Takeo; Hattori, Satoshi; Hanatani, Kaoru; Fukazawa, Yugo; Kobayashi, Kunihiko; Fujimoto, Seiichiro

doi:10.1016/s0002-9378(97)70082-6

Cited by 72 publications

(49 citation statements)

References 13 publications

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“…Premature infants who suffered from chorioamnionitis were reported to have significantly higher G-CSF levels in their umbilical cord blood than those without chorioamnionitis (16). In addition, as we have reported, premature infants who had chorioamnionitis with necrotizing funisitis at birth had significantly higher blood PMNL counts than those without this condition (10).…”

Section: Discussionsupporting

confidence: 67%

“…We previously reported that necrotizing funisitis was significantly associated with the development and exacerbation of CLD in premature infants and indicated that an increased polymorphonuclear leukocyte (PMNL) count in the fetal blood and the existence of some inflammatory inducer in the amniotic fluid appeared to have important roles in the genesis of CLD (10). To analyze the antenatal effects of inflammatory intensity or duration on fetal lung injury, however, an experimental animal model of necrotizing funisitis was needed.…”

mentioning

confidence: 99%

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Induction of Necrotizing Funisitis by Fetal Administration of Intravenous Granulocyte-Colony Stimulating Factor and Intra-Amniotic Endotoxin in Premature Fetal Sheep

et al. 2007

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Section: Discussionsupporting

confidence: 67%

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confidence: 99%

Induction of Necrotizing Funisitis by Fetal Administration of Intravenous Granulocyte-Colony Stimulating Factor and Intra-Amniotic Endotoxin in Premature Fetal Sheep

et al. 2007

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“…Others found significant correlation between necrotising funisitis and CLD. 30 Possible explanations for these differential effects include differentiated rates of co-morbidities, geographical and racial differences in cytokine response or organ susceptibility to cytokines, and different postnatal responses, which arise according to different in uterus environments. Our data, which show significant differences in delivery route, support this last explanation.…”

Section: Discussionmentioning

confidence: 99%

Preterm premature rupture of membranes, chorioamnion inflammatory scores and neonatal respiratory outcome

Zanardo¹,

Vedovato²,

Cosmi

et al. 2009

BJOG

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Objective To evaluate whether histological chorioamnionitis (HCA), in the setting of preterm premature rupture of membranes (PPROM), affects infant respiratory outcome.Design A prospective histological study on 287 consecutive placentas was performed in preterm infants (£32 +6 weeks gestation), categorised into four groups: according to the presence or absence of HCA, in the setting or in absence of PPROM. Results Among the 287 NICU admitted preterm infants, 68/287 (23.6%) presented with HCA, 16/68 (23.5%) with a coexisting fetal inflammatory response, and 74/287 (25.7%) with PPROM. HCA was associated with a greater frequency of vaginal delivery (P < 0.0001), lower gestational age (P < 0.0001) and lower birth weight (P < 0.01). HCA had no effect on fetal lung maturation, however, it was a significant risk factor for CLD (RR; 95% CI 2.08; 1.30-3.33). HCA and the fetal inflammatory response were also significant risk factors for PPROM (RR; 95% CI 2.07; 1.42-3.03 and 2.64; 1.71-4.09 respectively). Conversely, HCA in the setting of PPROM failed to reveal any RDS protection or subtype CLD risk. Multivariate analysis demonstrated significant independent effects of presence of maternal HCA (P = 0.04), gestational age (P < 0.0001) and interaction HCA-gestational age (P = 0.04) on CLD development, regardless of the presence of fetal HCA or fetal HCA-gestational age interaction, PPROM or PPROM-gestational age interaction.Conclusions Histological chorioamnionitis is a significant PPROM and CLD risk factor, but it fails to provide any protection from RDS. HCA in the setting of PPROM also failed to reveal any RDS protection or subtype CLD risk.Keywords Chronic lung disease, fetal inflammatory response syndrome, histological chorioamnionitis, preterm premature rupture of membranes, respiratory distress syndrome.Please cite this paper as: Zanardo V, Vedovato S, Cosmi E, Litta P, Cavallin F, Trevisanuto D, Chiarelli S. Preterm premature rupture of membranes, chorioamnion inflammatory scores and neonatal respiratory outcome. BJOG 2010;117:94-98.

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“…Later studies confirmed that CA, (2,3) funisitis, (4) and fetal inflammatory response syndrome (5,6) were associated with an increased incidence of BPD; however, results were not reproduced in some other studies. (7,8) It has been suggested that the association between CA and BPD is more complicated.…”

Section: Introductionmentioning

confidence: 94%

Cord blood interleukin-8 levels correlate with airway flow limitation at eight years of age in ex-very low birth weight infants

Gantar

Cerar

Babnik

et al. 2013

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Necrotizing funisitis: Clinical significance and association with chronic lung disease in premature infants

Cited by 72 publications

References 13 publications

Induction of Necrotizing Funisitis by Fetal Administration of Intravenous Granulocyte-Colony Stimulating Factor and Intra-Amniotic Endotoxin in Premature Fetal Sheep

Induction of Necrotizing Funisitis by Fetal Administration of Intravenous Granulocyte-Colony Stimulating Factor and Intra-Amniotic Endotoxin in Premature Fetal Sheep

Preterm premature rupture of membranes, chorioamnion inflammatory scores and neonatal respiratory outcome

Cord blood interleukin-8 levels correlate with airway flow limitation at eight years of age in ex-very low birth weight infants

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