Necrotizing fungal osteomyelitis and fingolimod, 4 years after treatment with fingolimod

Harirchian, Mohammad Hossein; Poursadeghfard, Maryam; Sadeghipour, Alireza; Kamali, Hoda; Sarraf, Payam

doi:10.1016/j.msard.2020.102021

Cited by 5 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors stated that bony involvement due to Cryptococcus species is uncommon, with an estimated prevalence of 5%, and virtually every bone could be involved. The current review revealed 106 more cases in adults including this present report [ 4 – 8 , 11 – 82 ] (Table 1 ).…”

Section: Review Of the Literaturementioning

confidence: 76%

“…[ 6 ] Hepatitis B Humerus, tibia Surgical debridement + antifungal treatment Delat and Laheri [ 17 ] Immunocompetent Scapula, tibia Surgical debridement + antifungal treatment Harirchian et al . [ 8 ] Multiple sclerosis Tibia Surgical debridement + antifungal treatment Annapureddy et al . [ 68 ] Pregnancy Tibia Surgical debridement + antifungal treatment Chokevittaya et al .…”

Section: Discussionmentioning

confidence: 99%

“…It may or may not be accompanied by periosteal reaction [ 1 ]. Defective cell immunity seems to play a vital role [ 8 ]. A cryptococcal lesion could prepare the ground for a pathologic fracture in a way that disturbs the distinctive properties of the bone.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cryptococcus neoformans osteomyelitis of the tibia: a case report and review of the literature

et al. 2023

View full text Add to dashboard Cite

Introduction Osteomyelitis is a bone inflammation that can be related to various infectious agents. As with any other type of inflammation, the prevailing symptoms and signs may include redness, swelling, pain, and heat. Fungal osteomyelitis is rare and usually found in immune-compromised patients. Case presentation A non-human immunodeficiency virus immunocompromised Greek female patient, 82 years old, visited the emergency department due to a 3 day pain located mainly over the left tibia’s anterior surface, accompanied by swelling and redness. There was also a subcutaneous lesion of her left breast. Medical history revealed that the patient had an unmasked close contact with pigeons, a main host of the disease. Initial x-ray imaging showed an osteolytic area in the upper third of the tibial diaphysis. The patient was admitted and underwent a computed tomography-guided biopsy. The specimen revealed a Cryptococcus neoformans infection of the bone and the breast. She was treated with 400 mg fluconazole twice a day for 3 weeks while in hospital and 200 mg twice a day upon discharge for 9 months. After that, she underwent surgical debridement because of lasting local irritation. She was closely monitored in our outpatient office, and in her last visit, 1 year after the initial admission, inflammatory signs had regressed vastly. Conclusions To our knowledge, this is the ninth cryptococcal osteomyelitis of the tibia to be recorded since 1974, and the most unusual finding was the bifocal nature of the infection, affecting both the tibia and the breast.

show abstract

Section: Review Of the Literaturementioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cryptococcus neoformans osteomyelitis of the tibia: a case report and review of the literature

et al. 2023

View full text Add to dashboard Cite

show abstract

“…We obtained the data of 25 individuals (from a total of 24 case reports) with herpes viral and cryptococcal infections associated with fingolimod and siponimod treatment (Table 3) (Patil et al, 2020;Carpenter et al, 2017;Gross et al, 2012;Dahshan et al, 2021;Harirchian et al, 2020;Muccilli et al, 2019;Hagiya et al, 2016;Kaur et al, 2020;Wienemann et al, 2020;Cuascut et al, 2019;Ma et al, 2020;Chong et al, 2019;Pham et al, 2017;Anene-Maidoh et al, 2017;Seto et al, 2016;Ward et al, 2016;Forrestel et al, 2016;Achtnichts et al, 2015;Huang, 2015;Issa and Hentati, 2015;Pfender et al, 2015;Uccelli et al, 2011; Key Safety Topics -Infections -Cryptococcal Meningitis 2021; Ratchford et al, 2012). Patients were mostly female (M: F: 11:14).…”

Section: Case Reportsmentioning

confidence: 99%

A comprehensive review of varicella-zoster virus, herpes simplex virus and cryptococcal infections associated with sphingosine-1-phosphate receptor modulators in multiple sclerosis patients

Sharma

Chaudhary

Beard

et al. 2022

Multiple Sclerosis and Related Disorders

View full text Add to dashboard Cite

Fingolimod

2020

Reactions Weekly

View full text Add to dashboard Cite

Necrotizing fungal osteomyelitis and fingolimod, 4 years after treatment with fingolimod

Cited by 5 publications

References 14 publications

Cryptococcus neoformans osteomyelitis of the tibia: a case report and review of the literature

Cryptococcus neoformans osteomyelitis of the tibia: a case report and review of the literature

A comprehensive review of varicella-zoster virus, herpes simplex virus and cryptococcal infections associated with sphingosine-1-phosphate receptor modulators in multiple sclerosis patients

Fingolimod

Contact Info

Product

Resources

About