Necrotizing fasciitis of the upper extremity: a retrospective analysis of 19 cases

Lemsanni, Meryem; Najeb, Y.; Zoukal, S.; Chafik, Rachid; Madhar, Mohammed; Elhaoury, Hanane

doi:10.1016/j.hansur.2021.02.004

Cited by 6 publications

(6 citation statements)

References 32 publications

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“…77 Similar results were observed by Lemsanni et al with wound preparation with NPWT and subsequent skin grafting. 78 The use of STSGs and full-thickness skin grafting for extremity wound reconstruction was also described by La Padula et al In their case series, only one flap (dorsal metacarpal artery flap) was performed in a secondary procedure for interphalangeal joint resurfacing. 79 Positive outcomes of skin grafting and NPWT for lower extremity NF have also been reported.…”

Section: Principles Of Managementmentioning

confidence: 94%

“…83 These procedures are relatively common, as up to one-quarter of NF patients still undergo amputation. 78,79,84 Perineum Defects (Fournier Defects)…”

Section: Coverage and Reconstructionmentioning

confidence: 99%

“…Research indicates that HBO improves patient survival while decreasing the number of surgical debridements and potentially the extent of reconstruction by inhibiting the systemic inflammatory response system and improving leukocyte activity. 78,109 Moreover, it can facilitate the transport of some antibiotics, such as aminoglycosides. 110 Risemann et al concluded that adjunct HBO therapy improved mortality from 66% to 23%.…”

Section: Principles Of Managementmentioning

confidence: 99%

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Practical Review of Necrotizing Fasciitis: Principles and Evidence-based Management

Guliyeva,

Huayllani,

Sharma

et al. 2024

Plastic and Reconstructive Surgery - Global Open

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Summary: Necrotizing fasciitis is a severe, life-threatening soft tissue infection that presents as a surgical emergency. It is characterized by a rapid progression of inflammation leading to extensive tissue necrosis and destruction. Nonetheless, the diagnosis might be missed or delayed due to variable and nonspecific clinical presentation, contributing to high mortality rates. Therefore, early diagnosis and prompt, aggressive medical and surgical treatment are paramount. In this review, we highlight the defining characteristics, pathophysiology, diagnostic modalities, current principles of treatment, and evolving management strategies of necrotizing fasciitis.

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Section: Principles Of Managementmentioning

confidence: 94%

“…83 These procedures are relatively common, as up to one-quarter of NF patients still undergo amputation. 78,79,84 Perineum Defects (Fournier Defects)…”

Section: Coverage and Reconstructionmentioning

confidence: 99%

Section: Principles Of Managementmentioning

confidence: 99%

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Practical Review of Necrotizing Fasciitis: Principles and Evidence-based Management

Guliyeva,

Huayllani,

Sharma

et al. 2024

Plastic and Reconstructive Surgery - Global Open

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“…Although the skin can return to a normal state and regain its regular function, a series of factors, such as infection, foreign body presence, tissue necrosis, and patient comorbidities, can disrupt its healing [4,5]. Therefore, a delay in wound closure increases the risk of bacterial colonization, invasion, and septicemia instauration leading patients to a life-threatening conditions [6,7].…”

Section: Introductionmentioning

confidence: 99%

Local anti-inflammatory effect and immunomodulatory activity of chitosan-based dressing in skin wound healing: a systematic review

2022

J Clin Transl Res

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Background and Aim: Wound healing is a complex process comprised of several distinct phases. An imbalance in any of the stages creates a chronic wound with the potential to cause life-threatening complications for patients. Chitosan (CS) is a biopolymer that has shown to positively impact the different healing phases. This systematic review aimed to evaluate the anti-inflammatory and immunomodulatory properties of CS-based wound therapy for the skin healing process after an injury. Methods: A systematic review was conducted in November 2021 following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. The PubMed, Embase, Google Scholar, and Cochrane online databases were queried to capture all publications in the past 10 years that investigated the CS effects on inflammation and immune reaction. Results: A total of 234 studies were screened after removing duplicates and 14 articles fulfilled our inclusion and exclusion criteria. In the studies, CS was combined with a wide range of products. One clinical trial was found that treated patients with diabetic foot ulcers. All animal models in the studies used a full-thickness skin wound to test the effectiveness of CS in the healing process. Decreased proinflammatory cytokine levels, a shortened inflammatory phase and accelerated wound closure was observed in all of the studies. Conclusions: CS proved to be a feasible, versatile, and multifaceted biomaterial that enhances the biological response to a skin injury. When combined with other products, its potential to boost the healing process through regulation of the inflammatory and cellular activity is increased. Relevance for Patients: Although few clinical trials have been completed, CS has become an excellent alternative to modulate the local inflammatory response promoting wound healing. Especially in patients with associated comorbidities that affect the typical resolution of skin healing, such as diabetes and vascular insufficiency. Therefore, using bioactive wound dressings based on CS combined with nanoparticles, growth factors, lived cells, or medications released in a controlled manner positively impacts patient life by shorting the wound healing process.

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“…1 Strong signs of NF, such as pain out of proportion, notable skin involvement, rapid progression of lesions, and hemodynamic instability, should lead to an elevated level of suspicion for the diagnosis of NSTI. 1,2 Necrotizing fasciitis is a true surgical emergency; when left untreated, it can lead to substantial mortality rates. 3 Treatment involves a multimodal approach with aggressive fluid resuscitation, proper antibiotic therapy, and urgent surgical debridement.…”

mentioning

confidence: 99%

Necrotizing Soft Tissue Infection of the Upper Extremity as a Manifestation of Hansen’s Disease

Bougioukli

Williams

Nwachuku

et al. 2022

Journal of Hand Surgery Global Online

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Necrotizing fasciitis of the upper extremity: a retrospective analysis of 19 cases

Cited by 6 publications

References 32 publications

Practical Review of Necrotizing Fasciitis: Principles and Evidence-based Management

Practical Review of Necrotizing Fasciitis: Principles and Evidence-based Management

Local anti-inflammatory effect and immunomodulatory activity of chitosan-based dressing in skin wound healing: a systematic review

Necrotizing Soft Tissue Infection of the Upper Extremity as a Manifestation of Hansen’s Disease

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