Necrotizing fasciitis due to Serratia marcescens: case report and review of the literature

Majumdar, Rohit; Crum-Cianflone, Nancy F.

doi:10.1007/s15010-015-0855-x

Cited by 8 publications

(18 citation statements)

References 21 publications

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“…38 There are 12 reports of occurrences subsequent to iatrogenic trauma, including 5 that occurred after surgery. 25,33,39-41 Other iatrogenic-associated cases followed skin or muscle biopsies, 42-44 IV catheter placement, 45,46 arteriovenous fistula, 26 and dermal filler injection. 47 One patient was described to have “minor trauma” of unspecified origin.…”

Section: Discussionmentioning

confidence: 99%

Severe and Progressive Cellulitis Caused by Serratia marcescens Following a Dog Scratch

Pithadia

Weathers

Colombo

et al. 2019

Journal of Investigative Medicine High Impact Case Reports

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Soft tissue infections occur in over 30% of patients with chemotherapy-induced neutropenia. Gram-positive bacterial infections predominate early in neutropenia, and likelihood of infection by resistant bacteria and fungi increases with prolonged neutropenia. Prior infections and exposures influence the risk of rare pathogens. A 55-year-old woman with chemotherapy-induced neutropenia was scratched on her forearm by a dog. She cleaned the wound with isopropanol and was treated empirically with amoxicillin-clavulanate. Over the next 4 days, she developed fever along with erythema, edema, and mild tenderness of the forearm without purulence or crepitus. She was hospitalized and received empiric treatment with intravenous vancomycin, piperacillin-tazobactam, tobramycin, and voriconazole. Despite therapy, her fevers persisted and the cellulitis progressed for over a week. After 10 days of hospitalization, her neutrophil count began to recover and a bulla developed at the wound site. Culture of the bullous fluid grew Serratia marcescens , and antibiotics were switched to cefepime based on susceptibility. She defervesced and showed substantial improvement of cellulitis within 48 hours and was discharged on oral ciprofloxacin. Serratia marcescens skin infections are rare, and this may be the first report of Serratia cellulitis associated with trauma from dog contact. This case highlights the need to consider unusual pathogens based on exposure history and immune status and to obtain cultures from fluid collections or tissue in cases of treatment-resistant soft tissue infections.

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Section: Discussionmentioning

confidence: 99%

Severe and Progressive Cellulitis Caused by Serratia marcescens Following a Dog Scratch

Pithadia

Weathers

Colombo

et al. 2019

Journal of Investigative Medicine High Impact Case Reports

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“…These are severe infections with a fatal course that are mostly observed in immunosuppressed patients. [ 13 – 16 ] We also observed S marcescens proliferate in the culture originating from the hemopurulent exudate sample that was taken from the SCC lesion.…”

Section: Discussionmentioning

confidence: 70%

An unusual location of squamous cell carcinoma and a rare cutaneous infection caused by serratia marcescens on the tumoral tissue

Sevencan¹,

Çakmaklıoğulları

Ozkan³

et al. 2018

Medicine

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Rationale:Serratia marcescens (S. marcescens) is an opportunistic pathogen of the Enterobacteriaceae family. Although S. marcescens is known to cause sepsis, meningitis, endocarditis, urinary system and ocular infections, skin infections are sporadic. Squamous cell carcinoma (SCC) is the most aggressive skin cancer type that is often located in the head and neck region, and rarely in the scalp tissue.Patient concerns:An 89-years-old male patient was diagnosed with SCC three years ago. The frontal region of the skull showed an ulcerated tumor, irregular borders, and exophytic growth pattern. The destruction of the frontal bone made the vibrating brain tissue visible, and the lower part had haemopurulent flow.Diagnoses:Gram staining showed the proliferation of gram (-) bacilli. Bacteria were identified as non-pigmented S. marcessens in the wound culture. To the best of our knowledge, there have not been any cases reported with S. marcescens causing cutaneous infections on SCC. Therefore, our report is the first case in the literature.Interventions:According to the culture antibiogram, S. marcescens was ciprofloxacin sensitive. Consequently, 1000 mg/day ciprofloxacin was initiated for 14 days.Outcomes:Purulent exudate in skin cancers may be caused by the nature of carcinoma tissue as well as the colonization of opportunistic pathogen microorganisms as seen in our patient.Lessons:Examination of the wound cultures and elimination of infections are critical in these cases.

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“…Prior literature review of cellulitis and NF due to S. marcescens identified 16 cases from 1966 to 2015. 1 To provide a review of recent cases of cellulitis and NF due to S. marcescens, we performed a systematic search of PubMed from 2015 to 2020 using the keywords Serratia marcescens and cellulitis, necrotizing fasciitis, and soft tissue infection (Table 1). Similar to earlier literature reviews, many patients in our review who developed S. marcescens cellulitis and NF were immunocompromised, most commonly with diabetes, heart failure, hypertension, lupus, malignancy, chronic venous insufficiency, chronic renal or end-stage renal disease, and advanced liver disease.…”

Section: Risk Factorsmentioning

confidence: 99%

Severe Skin Infections Due to Serratia marcescens

Gadhiya

Goldman

Panupong

et al. 2021

Infect Dis Clin Pract

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Necrotizing fasciitis due to Serratia marcescens: case report and review of the literature

Abstract: Our case and review highlight the potential risk factors for S. marcescens necrotizing fasciitis, including underlying renal disease and open wounds, and demonstrate the emergence of this organism as a cause of severe, life-threatening soft tissue infections.

Cited by 8 publications

References 21 publications

Severe and Progressive Cellulitis Caused by Serratia marcescens Following a Dog Scratch

Severe and Progressive Cellulitis Caused by Serratia marcescens Following a Dog Scratch

An unusual location of squamous cell carcinoma and a rare cutaneous infection caused by serratia marcescens on the tumoral tissue

Severe Skin Infections Due to Serratia marcescens

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