Necrotizing fasciitis as a complication of osteonecrosis of the jaw related to oral bisphosphonate application in a patient with osteoporosis: a case report

Steybe, David; Voss, Pit Jacob; Ermer, Michael Andreas; Fuessinger, Marc Anton; Schmelzeisen, Rainer; Poxleitner, Philipp

doi:10.1007/s10006-018-0725-7

Cited by 5 publications

(1 citation statement)

References 23 publications

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“…Microbial agents present in such pathologies are diverse, including Group A betahemolytic streptococci, MRSA (Methicillin-resistant Staphylococcus aureus), Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus epidermidis, Streptococcus milleri group, Acinetobacter sp., Enterobacter cloacae, and fungi. In the reported case, Acinetobacter cloacae was implicated, and, during hospitalization under antibiotic treatment, the patient developed a secondary infection with Clostridium difficile, leading to a transfer to an infectious disease unit [12,[25][26][27][28][29][30][31]. This led to the discontinuation of surgical treatment, exacerbating the immunosuppressive state and pre-existing imbalances [24,[32][33][34][35].…”

Section: Discussionmentioning

confidence: 91%

Periorbital Facial Necrotizing Fasciitis in Adults: A Rare Severe Disease with Complex Diagnosis and Surgical Treatment—A New Case Report and Systematic Review

Pertea,

Fotea,

Luca

et al. 2023

JPM

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(1) Background: Necrotizing fasciitis (NF) is a severe and aggressive pathology with a rapid progression and high mortality risk. Periocular NF is a rare condition associated with a lower mortality risk but significantly higher disabling sequelae. (2) Methods: We present the case of a 67-year-old homeless patient, a victim of assault, with multiple untreated comorbidities (diabetes mellitus, cardiac conditions, and schizophrenia) and a delayed diagnosis of periocular necrotizing fasciitis. The condition showed a cyclical evolution influenced by the existing comorbidities, and the patient underwent both surgical and medical treatment with a multidisciplinary team. Additionally, we report a systematic review of cases from the literature. (3) Results: The patient’s survival outcomes were favorable; however, the sequelae were disabling, not only concerning aesthetic aspects but also due to the loss of the affected eye globe. The systematic review revealed the rarity of such cases and the peculiarities of the presented case compared to those reported in the literature up to this point. (4) Conclusions: Understanding the signs, symptoms, and predisposing factors, as well as the potential rare localizations of NF, including the periocular region, can lead to the early diagnosis and treatment with good functional and aesthetic outcomes, minimizing significant disabilities.

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