Necrotizing fasciitis and myonecrosis “synergistic necrotizing cellulitis” caused by<i>Bacillus cereus</i>

Sada, Asuka; Misago, Noriyuki; Okawa, Takeshi; Narisawa, Yutaka; Ide, Seiji; Nagata, Masaki; Mitsumizo, Shinji

doi:10.1111/j.1346-8138.2009.00669.x

Cited by 12 publications

(10 citation statements)

References 9 publications

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“…When cultures grew B. cereus, antimicrobial therapy was changed, and the hyperbaric protocol was discontinued. An analogous case was described by Sada et al (113), that of a diabetic patient with alcoholic hepatop-athy who developed B. cereus fasciitis and myonecrosis. The patient was initially treated with penicillin on the basis of the presence of Gram-positive bacilli in smears of the lesion.…”

Section: Gas Gangrene-like Infectionssupporting

confidence: 52%

Bacillus cereus , a Volatile Human Pathogen

2010

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SUMMARY Bacillus cereus is a Gram-positive aerobic or facultatively anaerobic, motile, spore-forming, rod-shaped bacterium that is widely distributed environmentally. While B. cereus is associated mainly with food poisoning, it is being increasingly reported to be a cause of serious and potentially fatal non-gastrointestinal-tract infections. The pathogenicity of B. cereus, whether intestinal or nonintestinal, is intimately associated with the production of tissue-destructive exoenzymes. Among these secreted toxins are four hemolysins, three distinct phospholipases, an emesis-inducing toxin, and proteases. The major hurdle in evaluating B. cereus when isolated from a clinical specimen is overcoming its stigma as an insignificant contaminant. Outside its notoriety in association with food poisoning and severe eye infections, this bacterium has been incriminated in a multitude of other clinical conditions such as anthrax-like progressive pneumonia, fulminant sepsis, and devastating central nervous system infections, particularly in immunosuppressed individuals, intravenous drug abusers, and neonates. Its role in nosocomial acquired bacteremia and wound infections in postsurgical patients has also been well defined, especially when intravascular devices such as catheters are inserted. Primary cutaneous infections mimicking clostridial gas gangrene induced subsequent to trauma have also been well documented. B. cereus produces a potent β-lactamase conferring marked resistance to β-lactam antibiotics. Antimicrobials noted to be effective in the empirical management of a B. cereus infection while awaiting antimicrobial susceptibility results for the isolate include ciprofloxacin and vancomycin.

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Section: Gas Gangrene-like Infectionssupporting

confidence: 52%

Bacillus cereus , a Volatile Human Pathogen

2010

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“…For example, Bacillus subtilis is nonpathogenic, but its spores may contaminate environmental surfaces ( 1 ), including workbenches in laboratories and ventilation systems. In contrast, B. anthracis and B. cereus may be environmental contaminants, but these organisms are also important causes of human diseases, such as anthrax ( 2 – 4 ) and necrotizing fasciitis ( 5 , 6 ), respectively. Similarly, there are large numbers of clostridial species, the majority of which can cause human diseases if introduced to traumatized tissue, for example, Clostridium perfringens ( 7 , 8 ).…”

Section: Introductionmentioning

confidence: 99%

Glycerol Monolaurate (GML) and a Nonaqueous Five-Percent GML Gel Kill Bacillus and Clostridium Spores

Schlievert

Kilgore

Kaus

et al. 2018

mSphere

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Bacillus and Clostridium spores are known to be highly resistant to killing, persisting on environmental and human body surfaces for long periods of time. In favorable environments, these spores may germinate and cause human diseases. It is thus important to identify agents that can be used on both environmental and human skin and mucosal surfaces and that are effective in killing spores. We previously showed that the fatty acid monoester glycerol monolaurate (GML) kills stationary-phase cultures of Bacillus anthracis. Since such cultures are likely to contain spores, it is possible that GML and a human-use-approved GML nonaqueous gel would kill Bacillus and Clostridium spores. The significance of our studies is that we have identified GML, and, to a greater extent, GML solubilized in a nonaqueous gel, as effective in killing spores from both bacterial genera.

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“…Previous studies reported that Bacillus cereus-inducing necrotizing fasciitis commonly occurred in immunosuppressed patients [12], such as diabetes mellitus [13] and liver disease [11]. In our case, the patient only had a history of chronic obstructive pulmonary disease which impairs immune systems less than other underlying disease.…”

Section: Discussionmentioning

confidence: 58%

“…The presentation of Bacillus cereus infection, such as formation of gas or gangrene, may be similar to Clostridium species, which are sensitive to penicillin group. However, Bacillus cereus are resistant to β-lactam antibiotics, including penicillins and cephalosporins, due to the production of β-lactamase [11]. The aminoglycosides, clindamycin, vancomycin, chloramphenicol, erythromycin, and fluoroquinolones are susceptible for Bacillus cereus.…”

Section: Discussionmentioning

confidence: 99%

Bacillus cereus Induced Necrotizing Fasciitis Mimicking Gastroenteritis: A Case Report

Lee

Chen

Yiang

et al. 2018

Reports

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Necrotizing fasciitis is a rapidly spreading inflammation of the soft tissue involving the fascia and the subcutaneous tissue. Early and aggressive surgical intervention accompanied with appropriate antibiotics are the key to improve clinical outcome in patients with necrotizing fasciitis. Here, we present the case of a 46-year-old male who presented with acute onset progressive watery diarrhea and fever for one day. The abdominal ultrasound and computed tomography revealed diffuse gallbladder wall thickening with double layer sign, air density at right hepatic lobe and a small bowel edema. An intra-abdominal infection was initially suspected. However, a progressive erythematous change and bullae was found on the left thigh and lower abdomen. Progressed necrotizing fasciitis was suspected. After administration of broad antibiotics and emergency surgical intervention, the septic shock was reversed. Finally, the blood and wound culture reports revealed Bacillus cereus growth. This paper describes the clinical features of necrotizing fasciitis and highlights the Bacillus cereus-induced necrotizing fasciitis for physicians in order to promote timely intervention for septic shock.

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Necrotizing fasciitis and myonecrosis “synergistic necrotizing cellulitis” caused byBacillus cereus

Cited by 12 publications

References 9 publications

Bacillus cereus , a Volatile Human Pathogen

Bacillus cereus , a Volatile Human Pathogen

Glycerol Monolaurate (GML) and a Nonaqueous Five-Percent GML Gel Kill Bacillus and Clostridium Spores

Bacillus cereus Induced Necrotizing Fasciitis Mimicking Gastroenteritis: A Case Report

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