Necrotizing Fasciitis: A Life-Threatening Infection Due to Clostridium Species

Hechter, Sharon; Patel, Vraj; Bommu, Veera Jayasree Latha; Patel, Paresh V.; Ao, Xue; Alnabwani, Dina; Cheriyath, Pramil

doi:10.7759/cureus.22315

Cureus

2022

DOI: 10.7759/cureus.22315

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Necrotizing Fasciitis: A Life-Threatening Infection Due to Clostridium Species

Sharon Hechter¹,

Vraj Patel²,

Veera Jayasree Latha Bommu³

et al.

Abstract: Necrotizing fasciitis (NF), soft tissue infections, are rare but rapidly progressive and life-threatening infections with high morbidity and mortality rates. Early detection and intervention by physicians are paramount in mortality prevention. We present a case report of a 77-year-old female who presented with extensive NF due to a Clostridium septicum infection.

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Cited by 2 publications

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Fatal Clostridium septicum gas gangrene complicating ECMO: case report and review of literature

Turban,

Joussellin,

Piau

et al. 2024

Access Microbiology

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Clostridium septicum gas gangrene is a severe and deadly infection caused by an anaerobic, spore-forming, Gram-positive bacillus. As previously described, two entities are observed: traumatic and spontaneous (or non-traumatic) forms. In this report, we aim to describe the case of a fulminant and ultimately fatal C. septicum myonecrosis occurring in a patient who was first admitted for refractory cardiac arrest and placed on veino-arterial extracorporeal membrane oxygenation (ECMO). Building upon prior studies that have documented cases of spontaneous gas gangrene caused by C. septicum, we provide an updated compilation, focusing on microbiological characteristics of C. septicum, along with the diagnostic and therapeutic challenges associated with spontaneous gas gangrene. Additionally, the specific clinical situation of our case illustrates the seriousness of this infectious complication that combined both spontaneous and traumatic gas gangrene risk factors. We thus, discuss the antibiotic coverage prior to the initiation of ECMO procedure.

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Fatal Clostridium septicum gas gangrene complicating ECMO: case report and review of literature

Turban,

Joussellin,

Piau

et al. 2024

Access Microbiology

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Fatal Necrotizing Fasciitis Mediated by Escherichia coli After Parotidectomy and Neck Dissection: A Case Report and Review of the Literature

Abdallah,

Staibano,

Zhang

2023

Ear Nose Throat J

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Necrotizing soft tissue infection (NSTI) is a rare, but life-threatening, complication of head and neck surgery. We present a 70-year-old male with a history of immunosuppression who presented with polymicrobial NSTI following parotidectomy and neck dissection for cutaneous squamous cell carcinoma. The objective of this report was to promote awareness for NSTI following parotidectomy and selective neck dissection and highlight the management measures that can optimize survival outcomes. We performed a database search that identified 1,025 citations, of which 5 articles described classified as craniocervical necrotizing fasciitis following major head and neck surgery. Consent was obtained from the patient for inclusion in the research study and Institutional Review Board approval was waived. Our literature review yielded 6 cases of craniocervical necrotizing fasciitis following major head and neck surgery. This NSTI, however—unlike the others previously reported—was predominantly mediated by Escherichia coli, a bacterium associated with elevated mortality rates. Despite immediate awake fiberoptic intubation, repeated surgical debridement, and empirical antibiotic therapy, he deteriorated rapidly and was withdrawn from life-support on postoperative day seven. Prophylactic antibiotics, airway management, prompt diagnosis, and surgical debridement are critical for limiting mortality in NSTI of the head and neck.

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Necrotizing Fasciitis: A Life-Threatening Infection Due to Clostridium Species

Cited by 2 publications

References 11 publications

Fatal Clostridium septicum gas gangrene complicating ECMO: case report and review of literature

Fatal Clostridium septicum gas gangrene complicating ECMO: case report and review of literature

Fatal Necrotizing Fasciitis Mediated by Escherichia coli After Parotidectomy and Neck Dissection: A Case Report and Review of the Literature

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