Necrotizing fasciitis: a deadly infection

Kihiczak, George; Schwartz, Robert A.; Kapila, Rajendra

doi:10.1111/j.1468-3083.2006.01487.x

Cited by 100 publications

(124 citation statements)

References 33 publications

(80 reference statements)

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“…Multiple surgical procedures and even amputation may be necessary to contain the disease [3,7,8]. Medications can be administered to raise blood pressure and in some cases, a hyperbaric oxygen chamber may be helpful [2,4,5].…”

Section: Treatmentmentioning

confidence: 99%

“…The rarity of this disease combined with its initial clinical similarity to cellulitis makes prompt diagnosis diffi cult [2][3][4]10]. History of trauma, severe localized pain, heat and swelling, fl u-like symptoms, and redness are all common early indications of NF [1].…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Several serotype strains, M1 and M3 being the most prevalent within the United States, are known to cause NF [1][2][3][4]. This infection is generally community acquired and primarily occurs in the extreminities [2]. The fi rst account of NF dates back to 1783, when Claude Pouteau fi rst described the disease [1,3].…”

Section: Introductionmentioning

confidence: 99%

“…This adaptive human pathogen is wellknown for infecting the oropharynx resulting in pharyngitis. It can also contribute to more serious invasive diseases such as toxic-shock syndrome and necrotizing soft-tissue infections [1][2][3][4]. Several serotype strains, M1 and M3 being the most prevalent within the United States, are known to cause NF [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

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Necrotizing Fasciitis caused by Streptococcus pyogenes: A case report and literature review of disease diagnosis and management

Aziz¹

2017

Arch Community Med Public Health

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Background: A 55-year-old male presented to the emergency room at a local hospital complaining of chest discomfort and severe left elbow pain.Case Presentation: Erythema and symptoms of peripheral neuropathy were evident in the left hand. The patient reported recent trauma to his left elbow; however a radiograph of the left arm was unremarkable for fracture. After being admitted to the intensive care unit for observation, he developed worsening pain out of proportion and progressive decreased sensation in his left hand. Diagnosis:Initially, left arm compartment syndrome was suspected and treated accordingly. After surgical intervention, the patient's subsequent symptoms and preliminary blood culture results revealed Gram positive cocci in chains, indicating necrotizing fasciitis. The isolate was identifi ed as group A betahemolytic Streptococcus (GABS). Treatment and Follow-up:Broad-spectrum antibiotics given at outset were extended with additional antibiotics. Treatment consisted of fi ve separate surgeries involving extensive debridement of necrotic tissue amounting to approximately 55 to 65 percent of the patient's body surface area. The patient was eventually released to a burn center for skin grafting and wound closure and in less than three months, he expired.

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Section: Treatmentmentioning

confidence: 99%

Section: Clinical Presentationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Necrotizing Fasciitis caused by Streptococcus pyogenes: A case report and literature review of disease diagnosis and management

Aziz¹

2017

Arch Community Med Public Health

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“…Besides, within the spaces between subcutaneous tissue gasses as hydrogen, nitrogen, hydrogen sulfide, and methane can accumulate. [3] Fournier gangrene is seen 10 times more frequently in men than women. [4] Immune deficiency, diabetes, hypertension, alcoholism, malnutrition, obesity, low income level, and smoking are considered among risk factors.…”

Section: Introductionmentioning

confidence: 99%

Using negative pressure therapy for improving skin graft taking on genital area defects following Fournier gangrene

Orhan¹,

Senen²

2017

Turkish Journal of Urology

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Objective: Fournier's gangrene is an infective necrotizing fasciitis of the perineal, genital and perianal regions. Treatment includes aggressive surgical debridement that often results in extensive loss of genital skin. Skin grafts may be used for reconstruction but skin grafting of the male genitalia is diffucult because the penis and scrotum are mobile and deformable. A variety of methods are used to secure skin graft to recipient beds. We used negative pressure therapy (NPT) to secure skin grafts and improve skin graft taking. Material and methods:We used negative pressure therapy for graft fixation in 13 male patients who underwent debridements with the indication of Fournier gangrene, and whose defects formed were reconstructed with grafts between January 2009, and January 2014. Information about age of the patients, sessions of negative pressure therapy applied before, and after reconstruction, duration of hospital stay, and graft losses during postoperative period were recorded.Results: Median age of the patients was 56.15 (46-72) years. NPT was applied to patients for an average of 6.64 sessions (4-12) before and 1 sessions after graft reconstruction. Patients were hospitalized for an average of 26.7 (20-39) days. Any graft loss was not seen after NPT. Conclusion:Because of the peculiar anatomy of the genital region, anchoring of grafts is difficult so graft losses are often encountered. Use of NPT for ensuring graft fixation on the genital region prevents skin graft shearing.

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Bacterial Infections

Hay,

Morris‐Jones

2016

Rook's Textbook of Dermatology, Ninth Edition

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This chapter starts by considering the resident bacterial population of the skin and how this has altered with our growing understanding of the skin microbiome. It then reviews the whole range of bacterial skin infections from primary Gram‐positive infections due to staphylococci and streptococci to the less common infections caused by Gram‐negative and anaerobic bacteria. The cutaneous manifestations of common and rare systemic bacterial infections such as staphylococcal septicaemia and melioidosis are described in practical detail. Using new work on antibiotics, the spread of drug resistance amongst skin bacterial pathogens is reviewed and its relevance clarified in the treatment algorithms. Rickettsial infections are also considered.

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Necrotizing fasciitis: a deadly infection

Abstract: Necrotizing fasciitis (NF) is a life-threatening

Cited by 100 publications

References 33 publications

Necrotizing Fasciitis caused by Streptococcus pyogenes: A case report and literature review of disease diagnosis and management

Necrotizing Fasciitis caused by Streptococcus pyogenes: A case report and literature review of disease diagnosis and management

Using negative pressure therapy for improving skin graft taking on genital area defects following Fournier gangrene

Bacterial Infections

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