Necrotizing enterocolitis in preterm newborn with a history of maternal COVID-19: a case report

Nita, Rennilia; Aryati,; Matulatan, Fendy

doi:10.1016/j.radcr.2022.04.056

Cited by 3 publications

(2 citation statements)

References 8 publications

(20 reference statements)

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“…Despite this, the most appropriate probiotic has not been fully clarified (Figure 2) [43,44,70,95,102]. Noteworthily, during the recent COVID-19 pandemic, a rising number of NEC cases in several countries was reported [103][104][105][106][107]. How SARS-CoV-2 can promote NEC in neonates is still unclear, but we can hypothesize that the high affinity of the virus for the gut mucosa may have a role in such a process [108][109][110][111].…”

Section: The Role Of Intestinal Microbiotamentioning

confidence: 99%

Gut Microbiota and Immune System in Necrotizing Enterocolitis and Related Sepsis

Jirillo,

Topi,

Charitos

et al. 2024

Gastrointestinal Disorders

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A severe condition of sepsis can be a complication of necrotizing enterocolitis (NEC), which can occur in premature infants and becomes a medical challenge in the neonatal intensive care unit (NICU). It is a multifactorial intestinal disease (can affect both the small and large intestine) that can lead to ischemia of the intestinal tissues that evolves into acute organ necrosis. One of these factors is that different types of nutrition can influence the onset or the progression of the disease. Cow-milk-based infant formulas have been shown to cause it in premature infants more frequently than human milk. Recently, nutrition has been shown to be beneficial after surgery. Several issues still under study, such as the pathogenesis and the insufficient and often difficult therapeutic approach, as well as the lack of a common and effective prevention strategy, make this disease an enigma in daily clinical practice. Recent studies outlined the emerging role of the host immune system and resident gut microbiota, showing their close connection in NEC pathophysiology. In its initial stages, broad-spectrum antibiotics, bowel rest, and breastfeeding are currently used, as well as probiotics to help the development of the intestinal microbiota and its eubiosis. This paper aims to present the current knowledge and potential fields of research in NEC pathophysiology and therapeutic assessment.

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Section: The Role Of Intestinal Microbiotamentioning

confidence: 99%

Gut Microbiota and Immune System in Necrotizing Enterocolitis and Related Sepsis

Jirillo,

Topi,

Charitos

et al. 2024

Gastrointestinal Disorders

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“…Studies revealed that the prevalence rate of NEC was 4.87% in China ( 12 ), 25.4% in Addis Ababa ( 13 ), and 9.7% in Gurage ( 14 ). A study conducted in Indonesia found that 10% of full-term newborns had NEC ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

Risk factors of necrotizing enterocolitis among neonates admitted to the neonatal intensive care unit at the selected public hospitals in southern Ethiopia, 2023

Abebe,

Ayehu,

Tebeje

et al. 2024

Front. Pediatr.

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IntroductionNecrotizing enterocolitis (NEC) is a serious intestinal condition characterized by ischemic necrosis of the intestinal mucosa, inflammation, and invasion by gas-forming organisms, posing a significant threat to neonatal health. Necrotizing enterocolitis remains a significant cause of neonatal morbidity and mortality, particularly in developing countries. Due to limited research conducted in Ethiopia and the study area, there is a lack of information regarding the risk factors associated with necrotizing enterocolitis. Therefore, the goal of this study is to fill the aforementioned gap.ObjectiveThis study aims to identify the risk factors of necrotizing enterocolitis among neonates admitted to the neonatal intensive care unit (NICU) at selected general and referral hospitals in southern Ethiopia in the year 2023.Methods and materialsA facility-based unmatched case–control study was conducted. All neonates admitted to the NICU and diagnosed with necrotizing enterocolitis by the attending physician during the data collection period were considered as cases, whereas neonates admitted to the NICU but not diagnosed with necrotizing enterocolitis during the data collection period were considered as controls. Data were collected through face-to-face interviews and record reviews using the Kobo toolbox platform. The binary logistic regression method was used to determine the relationship between a dependent variable and independent variables. Finally, a p-value of < 0.05 was considered statistically significant.ResultsThis study included 111 cases and 332 controls. Normal BMI [AOR = 0.11, 95% CI: (0.02, 0.58)], history of khat chewing [AOR = 4.21, 95% CI: (1.96, 9.06)], term gestation [AOR = 0.06, 95% CI: (0.01, 0.18)], history of cigarette smoking [AOR = 2.86, 95% CI: (1.14, 7.14)], length of hospital stay [AOR = 3.3, 95% CI: (1.43, 7.67)], and premature rupture of membrane [AOR = 3.51, 95% CI: (1.77, 6.98)] were significantly associated with NEC.ConclusionThe study identified several risk factors for necrotizing enterocolitis, including body mass index, history of khat chewing, gestational age, history of cigarette smoking, length of hospital stays, and premature rupture of membrane. Therefore, healthcare providers should be aware of these risk factors to identify newborns at high risk and implement preventive measures.

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Neonatal outcomes of maternal prenatal coronavirus infection

Celik,

Tanacan,

Canpolat

2023

Pediatr Res

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Necrotizing enterocolitis in preterm newborn with a history of maternal COVID-19: a case report

Cited by 3 publications

References 8 publications

Gut Microbiota and Immune System in Necrotizing Enterocolitis and Related Sepsis

Gut Microbiota and Immune System in Necrotizing Enterocolitis and Related Sepsis

Risk factors of necrotizing enterocolitis among neonates admitted to the neonatal intensive care unit at the selected public hospitals in southern Ethiopia, 2023

Neonatal outcomes of maternal prenatal coronavirus infection

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