Necrotizing Enterocolitis in Full-term Neonates: Is it Aganglionosis?

Raboei, Enaam

doi:10.1055/s-0029-1202771

Cited by 28 publications

(26 citation statements)

References 15 publications

(23 reference statements)

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“…The more premature the neonate, the later this condition occurs (6). In term and late preterm neonates the disease usually occurs in the first week of life (5). All of our cases were preterm neonates and NEC occured mean 28±15 days after birth.…”

Section: Discussionmentioning

confidence: 61%

Severe IUGR and Long Duration of Antibiotic Treatment may Overcome the Benefits of Appropriate Feeeding Strategies to Prevent Necrotising Enterocolitis

2017

GMJ

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Aim: To compare the characteristic features of premature neonates who developed necrotizing enterocolitis (NEC) or not and review the risks for NEC in our neonatal intensive care unit. Materials and Method: Ninety four premature neonates with gestational age ≤ 35 weeks and/or birth weight ≤1500 g were included into the study. Characteristic features of the study neonates were compared. Results: NEC occurred in 15.9% of the study population. Seventy nine neonates who did not develop NEC and 15 neonates who developed stage II and III NEC were compared. The rate of intrauterine growth restriction (IUGR), late onset sepsis and therefore broad-spectrum antibiotic usage were significantly higher in the group who developed NEC. At the time of diagnosis 93 % of NEC positive patients were on full feeds either with breast milk only or breast milk + fortifier, none of them were formula fed, 7 % of the cases were never fed. Surgery was performed in all stage III NEC patients and overall mortality rate was 33%. Conclusion: Our findings suggest that together with exclusive breast feeding regimen, other strategies to prevent NEC should be implemented in this high risk preterm neonates.

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Section: Discussionmentioning

confidence: 61%

Severe IUGR and Long Duration of Antibiotic Treatment may Overcome the Benefits of Appropriate Feeeding Strategies to Prevent Necrotising Enterocolitis

2017

GMJ

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“…Prolonged rupture of the membranes, maternal infections, fetal distress, lower APGAR score, recurrent apneic episodes, hypotension, presence of intraumbilical vascular catheter, exchange transfusion, and PDA are some of the conditions leading to low-flow states and hypoxia. In full-term infants, NEC is seen considerably at an earlier stage, which is thought to be related to prematurely initiated formula feeding (2,4,5,(7)(8)(9)(10)(11)(12)(13)(14). As well as in our patient, a history of birth asphyxia secondary to prolonged labor and enteral feeding was elicited.…”

Section: Discussionmentioning

confidence: 99%

Neonatal colonic perforation

Saraç

Ataoğlu

Tatar

et al. 2015

UCD

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Neonatal colonic perforation is a rarely seen condition. Plain abdominal radiography of a 28-hour newborn consulted for vomiting and bloody stool revealed the presence of subdiaphragmatic free air, which necessitated surgical exploration. Transverse colonic perforation was detected during the exploration, and subsequently, a colostomy and appendectomy were performed. The postoperative follow-up period was uneventful. Necrotizing enterocolitis, Hirschsprung disease, and mechanical obstruction are some of the causes of colonic perforation during the neonatal period. Herein, we have shared a case of colonic perforation in an asphyctic newborn delivered after prolonged labor.

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“…[7] NEC in full-term infants accounts for 10% of all cases of NEC, and predominantly involves the colon. [13,14] Although the risk factors in full-term are congenital heart diseases, undiagnosed syndrome, birth asphyxia, intrauterine growth retardation and congenital hypothyroidism, but apparently, normal full-term infants may also develop NEC. [13,14] Localised or idiopathic perforation was described by Breslau in 1863 as "the perforation for which no other cause or NEC is found."…”

Section: Discussionmentioning

confidence: 99%

Six-year retrospective analysis of colonic perforation in neonates and infants: Single centre experience

Singh

Rawat

Wakhlu

et al. 2012

Afr J Paediatr Surg

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Necrotizing Enterocolitis in Full-term Neonates: Is it Aganglionosis?

Abstract: Our results support the suspicion that a large proportion of term neonates presenting with NEC have long segment or total colonic Hirschsprung's disease. This observation is in contrast to the currently available literature on this problem from the last decade.

Cited by 28 publications

References 15 publications

Severe IUGR and Long Duration of Antibiotic Treatment may Overcome the Benefits of Appropriate Feeeding Strategies to Prevent Necrotising Enterocolitis

Severe IUGR and Long Duration of Antibiotic Treatment may Overcome the Benefits of Appropriate Feeeding Strategies to Prevent Necrotising Enterocolitis

Neonatal colonic perforation

Six-year retrospective analysis of colonic perforation in neonates and infants: Single centre experience

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