Background: Although the safety and benefits of negative pressure wound therapy (NPWT) have been clearly demonstrated in the adult population, studies evaluating the safety and describing the use of NPWT in the pediatric population have been limited. Given this paucity, the goals of this study were to: (1) evaluate the literature dedicated to NPWT use in infants and children; and (2) leverage a population-level analysis to describe the experience of NPWT use in the pediatric population.