Necrotizing enterocolitis associated with Clostridium butyricum in a Japanese man

Abstract

CaseNecrotizing enterocolitis (NEC) caused by Clostridium butyricum is common in neonates; however, a case of NEC in adults has not been previously reported. An 84‐year‐old Japanese man developed C. butyricum‐related NEC during hospitalization for treatment of stab wounds to the left side of the neck and lower abdomen, without organ damage, and concomitant pneumonia.OutcomeThe patient developed acute onset of emesis accompanied by shock during his admission; partial resection of the small intestine was carried out due to necrosis. Pathologic findings showed mucosal necrosis and extensive vacuolation with gram‐positive rods in the necrotic small intestine. Blood culture tests revealed C. butyricum infection. The patient's condition improved after the surgery. He was moved to a rehabilitation hospital on day 66.ConclusionThis study suggests that hospitalized adult patients who receive antibiotic treatment are at risk for NEC.

Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 12: suitability of taxonomic units notified to EFSA until March 2020

“…The genetic locus coding for BoNT/E is generally harboured by megaplasmids (bigger than 500 Kb) as also confirmed by WGS (Halpin et al., ). C. butyricum has been identified as an aetiological cause of necrotising enterocolitis in preterm neonates (Cassir et al., ; Schönherr‐Hellec et al., ; Hosny et al., ,b) and in adults (Sato et al., ). The strains isolated from necrotising enterocolitis harbour four genes encoding polypeptides similar to haemolysins (Cassir et al., ).…”

In Vitro Antimicrobial Activity and Probiotic Potential of Bifidobacterium and Lactobacillus against Species of Clostridium

“…[ 24 ]. Recent studies point to Clostridium butyricum as an important cause of NEC [ 25 , 26 , 27 ], although there are non-toxigenic strains that can be employed as probiotics [ 28 ].…”

Rapidly Fatal Postlaparoscopic Liver Infection from the Rarely Isolated Species Clostridium butyricum

“…It is found both in the environment (as a soil bacterium) and in fecal isolates from humans and animals. C. butyricum is rarely reported as a human pathogen, but it has been implicated in various types of infections, including necrotizing enterocolitis [5][6][7][8], polymicrobial peritonitis [9], type E botulism [10,11], and several cases of C. butyricum bacteremia [12,13]. C. butyricum sepsis occurred in one patient that injected cocaine into his indwelling central venous catheter [14].…”