Necrotizing enterocolitis and human milk

Moriartey, R.R.; Finer, Neil N.; Cox, Sharon; Phillips, H.J.; Theman, A.; Stewart, A.; Ulan, O. A.

doi:10.1016/s0022-3476(79)80848-3

Cited by 40 publications

(6 citation statements)

References 3 publications

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“…Although we favored alimentation with maternal breast milk even in VLBW infants (28), pasteurized human milk (29) and breast milk were not exclusion criteria because we had seen several cases of NEC in exclusively breast-fed infants prior to this study. Similar cases have been reported by other authors (30)(31)(32).…”

Section: Discussionsupporting

confidence: 92%

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Necrotizing enterocolitis prophylaxis: oral antibiotics and lyophilized enterobacteria vs oral immunoglobulins

Fast

Rosegger

1994

Acta Paediatrica

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We conducted a prospective randomized trial to compare the efficacy of oral gentamicin versus oral IgA‐IgG for the prophylaxis of necrotizing enterocolitis (NEC); 200 newborns considered at high risk for NEC were assigned to group A (oral IgA‐IgG, n= 100) or group B (oral Gentamicin, n= 100). NEC was diagnosed in 13 cases in group A and in 1 case in group B between the 3rd and 16th days of life. Surgical treatment was necessary in 3 cases (2 in group A). All infants survived. We conclude that oral gentamicin is more effective than oral IgA‐IgG in the prevention of NEC in infants at high risk.

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Section: Discussionsupporting

confidence: 92%

“…Eight (57%) of 14 infants with NEC had stool 9.0 f 0.9 7.21 i 0.1 1 7.15f0.11 (29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43) (730-4350)…”

Section: Resultsmentioning

confidence: 99%

Necrotizing enterocolitis prophylaxis: oral antibiotics and lyophilized enterobacteria vs oral immunoglobulins

Fast

Rosegger

1994

Acta Paediatrica

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“…36]. NEC has been reported in premature newborns fed frozen human milk [37] or refrigerated human milk. In our study, only 3 full-term babies were breast-fed.…”

Section: Discussionmentioning

confidence: 99%

Necrotizing Enterocolitis in Full-Term Newborns

Gamarra¹,

Helardot²,

Moriette³

et al. 1983

Neonatology

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During a 17-month period, 19 full-term newborn infants were hospitalized for necrotizing enterocolitis (NEC). 10 of these infants had no apparent risk factors. Only 7 suffered acute fetal distress. 16 of the 19 infants were born in the same hospital. Toxicological and bacteriological investigations of possible cause revealed no specific agent. Virological analysis of 8 stool samples revealed the presence of corona virus in 5 of the 8.

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“…Our finding of a protective effect of expressed breast milk is in agreement with the recent report of Lucas and Cole.6 Such a protective effect may have been missed in previous studies because of small numbers of babies who received breast milk, or failure to control for gestational age. For example, in two studies the babies receiving expressed breast milk had a lower mean gestational age than those who received formula.21 22 Hence, as can be seen from fig 1, they would be expected to have an increased incidence of NEC that may have offset any improvement due to the expressed breast milk. The finding of a protective effect caused by the expressed breast milk is further supported by the prospective study of Eibl et al in which an oral immunoglobulin A/immunoglobulin G mixture was found to significantly reduce the incidence of NEC.23…”

Section: Group With Spontaneous Perforationmentioning

confidence: 99%

Risk factors for necrotising enterocolitis: the influence of gestational age.

Beeby

Jeffery

1992

Archives of Disease in Childhood

136

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Over a 7 year study period, 82 infants were identified who had necrotising enterocolitis (NEC). A case-control study of the 74 preterm infants was performed to determine those factors which contributed to the development of NEC. The 35 infants with NEC and gestation between 30-36 weeks, when compared with control infants matched for gestational age, had significantly lower birthweight centiles, cord pH, and 1 minute Apgar scores. By contrast, there were no significant differences between the 39 infants with NEC and controls in the 25-29 week group, except that fewer babies with NEC had received breast milk. The eight term babies all appeared to have an obvious predisposing event. We thus propose a model in which susceptibility to NEC is dependent on gestational age. In the 25-29 week range all babies are at risk on the basis of extreme prematurity. In the 30-36 week range asphyxiated and growth retarded babies are at increased risk, while at term a major predisposing event appears to be required.

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Necrotizing enterocolitis and human milk

Cited by 40 publications

References 3 publications

Necrotizing enterocolitis prophylaxis: oral antibiotics and lyophilized enterobacteria vs oral immunoglobulins

Necrotizing enterocolitis prophylaxis: oral antibiotics and lyophilized enterobacteria vs oral immunoglobulins

Necrotizing Enterocolitis in Full-Term Newborns

Risk factors for necrotising enterocolitis: the influence of gestational age.

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