Necrotizing Crescentic Glomerulonephritis Complicating Bivalvular Bacterial Endocarditis

Abstract

In the setting of an increasing incidence of endocarditis in the United States, we report a patient with necrotizing crescentic glomerulonephritis (GN) associated with native valve bacterial endocarditis due to Streptococcus parasanguinis. He was started on appropriate antibiotic treatment and subsequent blood cultures showed no growth. However, due to continuing decline in kidney function, immunosuppressive therapy was started. Despite immunosuppressive therapy and antibiotics, renal function did not improve and chronic hemodialysis was required. Due to rarity of condition, there are no definite treatment guidelines available. Antibiotics, steroids, immunosuppressive agents can be of help in most cases. Further research in this regard may help with early diagnosis and better treatment modalities.

Actinomyces as a Cause of Unexplained Fever Diagnosed by Next-Generation Sequencing: Case Report and Review

“…V.atypica is one early-colonizing members of the dental plaque bio lm [25], but to our knowledge have not been recognized as causative agents of disease in respiratory system. There are only occasional reports of endocarditis due to S. parasanguinis [26]. P. melaninogenica is often associated with pyomyositis [27].…”