Necrotizing autoimmune myositis following coronavirus disease 2019 infection: a case report

Loghman, Maryam; Rahmanian, Ehsan; Alikhani, Majid; Saffar, Hiva; Hezaveh, Sara Beikmohamadi; Nekooeian, Mohammad; Shahriarirad, Reza; Faezi, Seyedeh Tahereh

doi:10.1186/s13256-022-03680-5

Cited by 4 publications

(2 citation statements)

References 43 publications

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“…Upper leg MRI also did not reveal signs of myositis, which is consistent with recently published radiological findings (50). However, biopsies were taken almost a year after acute infection and several case reports of biopsy-proven myositis after SARS-CoV-2 have been published (51)(52)(53), and we ourselves histologically diagnosed non-specific myositis in some patients in the subacute aftermath of mild or moderate COVID (Fig. S3F).…”

Section: Discussionsupporting

confidence: 90%

Post-COVID syndrome is associated with capillary alterations, macrophage infiltration and distinct transcriptomic signatures in skeletal muscles

Aschman

Wyler

Baum

et al. 2023

Preprint

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The SARS-CoV-2 pandemic not only resulted in millions of acute infections worldwide, but also caused innumerable cases of post-infectious syndromes, colloquially referred to as long COVID. Due to the heterogeneous nature of symptoms and scarcity of available tissue samples, little is known about the underlying mechanisms. We present an in-depth analysis of skeletal muscle biopsies obtained from eleven patients suffering from enduring fatigue and post-exertional malaise after an infection with SARS-CoV-2. Compared to two independent historical control cohorts, patients with post-COVID exertion intolerance had fewer capillaries, thicker capillary basement membranes and increased numbers of CD169+ macrophages. SARS-CoV-2 RNA could not be detected in the muscle tissues, but transcriptomic analysis revealed distinct gene signatures compared to the two control cohorts, indicating immune dysregulations and altered metabolic pathways. We hypothesize that the initial viral infection may have caused immune-mediated structural changes of the microvasculature, potentially explaining the exercise-dependent fatigue and muscle pain.

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Section: Discussionsupporting

confidence: 90%

Post-COVID syndrome is associated with capillary alterations, macrophage infiltration and distinct transcriptomic signatures in skeletal muscles

Aschman

Wyler

Baum

et al. 2023

Preprint

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“…Studies regarding SARS-CoV-2-induced IIM are lacking. Review of the literature yields mostly single case reports (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) , with larger case series referring to SARS-CoV-2 vaccines (21,22). Certainly, higher-level evidence is still required to discern whether the incidence of IIM has increased during the pandemic and whether the disease pattern and course have changed.…”

Section: Infectious Diseases Have Long Been Linked To the Development...mentioning

confidence: 99%

Increased rates of idiopathic inflammatory myopathies during the COVID-19 pandemic: a single-centre experience

Kharouf

Kenig

Bohbot

et al. 2023

Clinical and Experimental Rheumatology

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ObjectiveHigher-level evidence is required to discern whether the incidence of idiopathic inflammatory myopathies (IIM) has increased during the COVID-19 pandemic and whether the disease pattern and course have changed. We aimed to analyse patients who were diagnosed with IIM at our tertiary care centre during the pandemic and compare them with IIM patients diagnosed before COVID-19. MethodsWe retrospectively analysed the medical records of adult patients (>18 years) who were diagnosed with IIM during COVID-19 versus a control group of patients diagnosed before the outbreak. Included were patients whose diagnosis was made at the

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Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles

Aschman,

Wyler,

Baum

et al. 2023

acta neuropathol commun

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The SARS-CoV-2 pandemic not only resulted in millions of acute infections worldwide, but also in many cases of post-infectious syndromes, colloquially referred to as “long COVID”. Due to the heterogeneous nature of symptoms and scarcity of available tissue samples, little is known about the underlying mechanisms. We present an in-depth analysis of skeletal muscle biopsies obtained from eleven patients suffering from enduring fatigue and post-exertional malaise after an infection with SARS-CoV-2. Compared to two independent historical control cohorts, patients with post-COVID exertion intolerance had fewer capillaries, thicker capillary basement membranes and increased numbers of CD169+ macrophages. SARS-CoV-2 RNA could not be detected in the muscle tissues. In addition, complement system related proteins were more abundant in the serum of patients with PCS, matching observations on the transcriptomic level in the muscle tissue. We hypothesize that the initial viral infection may have caused immune-mediated structural changes of the microvasculature, potentially explaining the exercise-dependent fatigue and muscle pain. Graphical Abstract

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Necrotizing autoimmune myositis following coronavirus disease 2019 infection: a case report

Cited by 4 publications

References 43 publications

Post-COVID syndrome is associated with capillary alterations, macrophage infiltration and distinct transcriptomic signatures in skeletal muscles

Post-COVID syndrome is associated with capillary alterations, macrophage infiltration and distinct transcriptomic signatures in skeletal muscles

Increased rates of idiopathic inflammatory myopathies during the COVID-19 pandemic: a single-centre experience

Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles

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