Necrotic cellulitis by Serratia plymuthica

Pérez, Reyes Pascual; Moro, Cristina Galvañ; Tenza, Isabel Pacheco; Aranda, Adolfo Morente; Garcı́a, Hugo Briceño; Barba, C. Pérez

doi:10.1016/j.ejim.2003.09.010

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…S. plymuthica was recovered from both blood cultures and from cellulitis cultures. Surgical exploration, debridement, and therapy with imipenem were successful in treating the infection (298). The organism was also involved in a case of septic pseudoarthrosis published in 2008 from a 17-year-old patient with postoperative left thigh pain.…”

Section: S Plymuthicamentioning

confidence: 98%

Serratia Infections: from Military Experiments to Current Practice

2011

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SUMMARY Serratia species, in particular Serratia marcescens , are significant human pathogens. S. marcescens has a long and interesting taxonomic, medical experimentation, military experimentation, and human clinical infection history. The organisms in this genus, particularly S. marcescens , were long thought to be nonpathogenic. Because S. marcescens was thought to be a nonpathogen and is usually red pigmented, the U.S. military conducted experiments that attempted to ascertain the spread of this organism released over large areas. In the process, members of both the public and the military were exposed to S. marcescens , and this was uncovered by the press in the 1970s, leading to U.S. congressional hearings. S. marcescens was found to be a certain human pathogen by the mid-1960s. S. marcescens and S. liquefaciens have been isolated as causative agents of numerous outbreaks and opportunistic infections, and the association of these organisms with point sources such as medical devices and various solutions given to hospitalized patients is striking. Serratia species appear to be common environmental organisms, and this helps to explain the large number of nosocomial infections due to these bacteria. Since many nosocomial infections are caused by multiply antibiotic-resistant strains of S. marcescens , this increases the danger to hospitalized patients, and hospital personnel should be vigilant in preventing nosocomial outbreaks due to this organism. S. marcescens , and probably other species in the genus, carries several antibiotic resistance determinants and is also capable of acquiring resistance genes. S. marcescens and S. liquefaciens are usually identified well in the clinical laboratory, but the other species are rare enough that laboratory technologists may not recognize them. 16S rRNA gene sequencing may enable better identification of some of the less common Serratia species.

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Section: S Plymuthicamentioning

confidence: 98%

Serratia Infections: from Military Experiments to Current Practice

2011

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“…5 The identity of the production strain is based on . 6 S. plymuthica has been associated with occasional cases of infections (Carrero et al, 1995;Pascual P erez et al, 2003). The main virulence factor of the genus Serratia is a haemolysin.…”

Section: Source Of the Food Enzymementioning

confidence: 99%

Safety evaluation of the food enzyme preparation isomaltulose synthase from Serratia plymuthica strain Z12A

Silano¹,

Baviera²,

Bolognesi³

et al. 2021

EFS2

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The food enzyme isomaltulose synthase (sucrose glucosylmutase; EC 5.4.99.11) is produced with Serratia plymuthica strain Z12A by BENEO ‐Palatinit GmbH. The food enzyme is used only in the form of an immobilised preparation of non‐viable cells for the production of isomaltulose. Residual amounts of total organic solids ( TOS ) are removed by the purification steps applied during the production of isomaltulose consequently, dietary exposure was not calculated. Genotoxicity tests did not indicate safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 1,011 mg TOS /kg body weight (bw) per day, the highest dose tested. Similarity of the amino acid sequence of the enzyme to those of known allergens was searched and no match was found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood of such reactions to occur is considered to be low. Based on the data provided, the use of an immobilised food enzyme and the removal of TOS during the production of isomaltulose the Panel concluded that this food enzyme preparation does not give rise to safety concerns under the intended conditions of use.

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Serratia plymuthica: A community-acquired uropathogen

2017

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<p class="ABS">There is paucity in information on Serratia plymuthica causing human infections. Only few case reports worldwide have documented this organism as a pathogen causing human infections till date. We describe here a case of community-acquired urinary tract infection caused by S. plymuthica in an elderly man. To our knowledge, this is first human case report describing S. plymuthica as uropathogen.</p><div> </div>

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Necrotic cellulitis by Serratia plymuthica

Cited by 3 publications

References 11 publications

Serratia Infections: from Military Experiments to Current Practice

Serratia Infections: from Military Experiments to Current Practice

Safety evaluation of the food enzyme preparation isomaltulose synthase from Serratia plymuthica strain Z12A

Serratia plymuthica: A community-acquired uropathogen

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