Necrosulfonamide – Unexpected effect in the course of a sulfur mustard intoxication

Necrosulfonamide Selectively Induces DNA Double-Strand Breaks in Acute Myeloid Leukemia Cells

“…However, in both human and mouse cells, NSA directly binds to gasdermin D (GSDMD), the pyroptotic pore-forming protein, inhibiting GSDMD oligomerization and pyroptotic cell death . Based on the inhibitory activity of NSA, several studies have attempted to use NSA to treat injuries involving necroptosis, such as spinal cord injury, , pulmonary ischemia–reperfusion injury, and sulfur mustard intoxication …”

“…3 Based on the inhibitory activity of NSA, several studies have attempted to use NSA to treat injuries involving necroptosis, such as spinal cord injury, 6,7 pulmonary ischemia− reperfusion injury, 8 and sulfur mustard intoxication. 9 NSA is a small crescent-shaped molecule containing unfused planar aromatic heterocyclic structures linked by bonds with torsional freedom (Figure 1A), which might allow NSA to bind with DNA. However, it is not known whether NSA is genotoxic.…”