Necrosis of the Renal Papillae and Prolonged Abuse of Phenacetin

Observations on the Effect of Phenacetin and N‐acetyl‐p‐aminophenol on Rat Kidneys

“…Nor was it possible to establish another property, which could perhaps be regarded as a special feature of the renal lesions observed in connection with phenacetin, viz. fairly common papillary necrosis (Spiihler and Zollinger 1953, Uehlinger 1958, Lindeneg et al 1959). The lastmentioned change generally occurs in chronic states, whereas the changes observed in the present experiments can probably be regarded as relatively acute.…”

The Renal Concentrating Capacity in Albino Rats after Long‐term Consumption of Phenacetin, NAPA (N‐acetyl‐p‐aminophenol) and Acetylsalicylic Acid

“…Clinically a relationship exists between phenacetin abuse and renal papillary necrosis (3, 6, 7, 8,9,11,12,14,15). Therefore, it is probable that the concentrating capacity is one of the renal tubular functions that will be affected earliest during phenacetin consumption.…”

“…During recent years several investigators have presented clinical data indicating a nephrotoxic effect from phenacetin (3, 7, 8,9,11,12,14). There are also animal experiments suggesting such an effect (1,2,10,15).…”

Phenacetin Takers Dead with Renal Failure

“…Spuhler and Zollinger in 1953 had already noted this connection and later many other Swiss authors, among others TholCn et al (1956), Gsell et al (1957), Moeschlin (1957) and Danish authors, among others West (1957), Larsen and Moller (1958), Lindeneg et al (1959) have supported this view. There were, however, also those who made critical comments on this point.…”