Necrosis of the glans penis secondary to calciphylaxis

Abstract

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Cutaneous calciphylaxis of the glans penis presenting as a gangrenous ulceration

“…Penile involvement is a rare distal manifestation of calciphylaxis; it manifests with black eschars and necrosis mimicking a wound [13][14][15]. Our case suggests that mucosal necrosis may have a moist and whitish appearance.…”

Penile calciphylaxis in a patient with end-stage renal disease and chronic hemodialysis: a case report

“…For both non-penile cutaneous calcific uremic arteriolopathy and non-cutaneous calcific uremic arteriolopathy, the widely used treatment is the conservative management of penile calciphylaxis mirrors. The management of less severe cases of penile calciphylaxis consists of local wound debridement, analgesia, and normalization of metabolic dysregulation [ 10 , 11 ]. In the presence of secondary hyperparathyroidism associated with hypercalcemia and/or hyperphosphatemia, medical treatment is based on phosphorus binders (sevelamer) and a calcimimetic agent (cinacalcet) [ 11 , 12 ].…”

A rapid unfavorable penile calciphylaxis case followed by total penectomy

“…The calcifications are thin and predominantly vascular. However, performing a deep skin biopsy in cases of penile calciphylaxis remains yet controversial because it could activate the evolution of the pathology and favor penile necrosis 9,10 . This highlights the importance of noninvasive imaging methods to visualize the calcifications of the vessels characteristic of calciphylaxis.…”