Necrosis of the femoral head in growing rats: Occlusion of lateral epiphyseal vessels

Hirano, Tôru; Iwasaki, Katsurô; Sagara, Kozo; Nishimura, Yukimasa; Kumashiro, Toshiyuki

doi:10.3109/17453678909149307

Cited by 23 publications

(7 citation statements)

References 8 publications

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“…Hirano, Iwasaki, and others have observed osteonecrosis in the femoral head of spontaneously hypertensive rats [29][30][31]. Appearing 7-15 weeks after birth, the lesion undergoes complete repair by granulation tissue.…”

Section: Animal Models In Ratsmentioning

confidence: 95%

“…Appearing 7-15 weeks after birth, the lesion undergoes complete repair by granulation tissue. There is a disturbed ossification in the proximal femoral epiphysis and systemic skeletal growth retardation [30,31]. Kikkawa et al [32] observed that osteonecrosis was actually preceded by a disturbance of cartilage mineralization and abnormal development of the femoral epiphysis.…”

Section: Animal Models In Ratsmentioning

confidence: 98%

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Animal Models of Osteonecrosis

Jones

Allen

2011

Clinic Rev Bone Miner Metab

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Section: Animal Models In Ratsmentioning

confidence: 95%

Section: Animal Models In Ratsmentioning

confidence: 98%

Animal Models of Osteonecrosis

Jones

Allen

2011

Clinic Rev Bone Miner Metab

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“…ONFH observed in spontaneously hypertensive stroke-prone (SHRSP) rats closely resembles human ONFH, not only histologically but also physiologically (Hirano et al 1989, Wada et al 2004, Murata et al 2007, Suzuki et al 2008). We have reported a 50% incidence of spontaneous osteonecrosis of the femoral head in SHRSP rats at the age of 16–18 weeks, and they develop ONFH more frequently (up to 90%) with steroid administration (Murata et al 2007, Suzuki et al 2008).…”

mentioning

confidence: 86%

Pravastatin reduces steroid-induced osteonecrosis of the femoral head in SHRSP rats

Nozaki¹,

Kumagai²,

Miyata³

et al. 2012

Acta Orthopaedica

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Background and purpose Although the definite cause of steroid-induced osteonecrosis of the femoral head (ONFH) is unknown, peripheral circulatory failure, lipid metabolism disturbance, and increased oxidative stress are considered to be possible causes. We investigated whether pravastatin as a statin treatment reduces (1) the incidence of ONFH, (2) the adipocyte area, and (3) bone marrow changes in the femoral head.Methods We divided up 81 thirteen-week-old spontaneously hypertensive stroke-prone (SHRSP)/Izm male rats into 4 groups: a control group (group C), a group given pravastatin (group P), a group given steroid (group S), and a group given both pravastatin and steroid (Group PS). The steroid was administered at 15 weeks of age. Pravastatin, as a statin, was administered in the drinking water for 4 weeks. The rats were killed when 17 weeks old. Osteonecrosis was diagnosed based on histopathological examination. Oxidative stress was assessed from immunostaining.Results The incidence of histological osteonecrosis was lower in the groups given pravastatin. The percentage of adipocyte area in the bone marrow was lower in the PS group than in the S group. Immunohistochemical staining for oxidative stress showed that staining was less in the PS group than in the S group. Pravastatin had no effect on the blood-derived biochemical findings on lipid metabolism. However, it reduced the incidence of steroid-induced ONFH in these SHRSP rats. We presume that this occurred by reducing oxidative stress and by reducing the percentage of adipocyte area in the femoral heads.Interpretation Our data suggest that pravastatin may be effective in reducing steroid-induced ONFH.

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“…Therefore, the blood supply to the femoral capital epiphysis in SHRs would be similar to that in children. Hirano et al (1989) suggested that the occlusion of the lateral epiphyseal vessels occurred in the region between the articular cartilage and the growth plate where the cartilage forms a canal. They assumed that the occlusion was due to the destruction of the canal, because abnormal findings, such as disorganized patterns and nodular proliferation of chondrocytes, were frequently seen there.…”

Section: Discussionmentioning

confidence: 99%