Necrosis of Subcutaneous Fat with Hypercalcemia

Sharlin, David N.; Koblenzer, Peter J.

doi:10.1177/000992287000900517

Cited by 24 publications

(11 citation statements)

References 7 publications

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“…The relative decrease in unsaturated fatty acids suggested the possibility of arrested development of fat metabolism (18). X-ray diffraction techniques confirmed that the crystals are essentially triglycerides and also supported the presence of an increased saturated: unsaturated fatty acid ratio (12, 16,19,20).…”

mentioning

confidence: 73%

Sclerema Neonatorum and Subcutaneous Fat Necrosis of the Newborn

Fretzin

Arias

1987

Pediatric Dermatology

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mentioning

confidence: 73%

Sclerema Neonatorum and Subcutaneous Fat Necrosis of the Newborn

Fretzin

Arias

1987

Pediatric Dermatology

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“…Hypercalcemia in SCFN (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) is a relatively rare complication that may result in death secondary to its sequelae (10,13,15). Review of all 20 reported cases ( Table 2) indicates that the typical neonate is approximately 1 week postterm.…”

Section: Discussionmentioning

confidence: 99%

“…Hypercalcemia occurs one to four months after onset of the skin lesions. Since the association between SCFN and hypercalcemia was made in 1926 (5), only 19 cases have been reported in the literature (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Three of the neonates died due to the sequelae of hypercalcemia (10,13,15).…”

mentioning

confidence: 99%

Subcutaneous Fat Necrosis of the Newborn and Hypercalcemia: Case Report and Review of the Literature

Hicks

Levy

Alexander

et al. 1993

Pediatric Dermatology

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Subcutaneous fat necrosis of the newborn (SCFN) alone is an uncommon condition. Its association with hypercalcemia has been reported in 19 neonates since 1926. The two occur in full-term to postterm newborns with perinatal complications associated with delivery. Erythematous to violaceous, firm, subcutaneous nodules appear approximately 1 to 4 weeks after delivery, preceding the development of signs and symptoms of hypercalcemia. Although SCFN and hypercalcemia are rare complications in neonates with perinatal problems, death due to the sequelae of hypercalcemia occurred in 3 of the 19 patients. A neonate who develops skin lesions consistent with SCFN should be followed for possible onset of hypercalcemia and treated in a timely fashion.

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“…The condition generally runs a benign course, with resolution in a matter of weeks. Hypercalcemia occurs occasionally in infants with SCFN, and may be associated with anorexia, vomiting, and failure to thrive (6)(7)(8)(17)(18)(19). The cause of hypercalcemia is not understood.…”

Section: Discussionmentioning

confidence: 99%

“…Parathormone and vitamin D levels are nearly always normal (6,19). Release of calcium from deposits in the necrotic lesions has been suggested as an explanation; however, most infants with hypercalcemia do not have evidence of calcium deposition in the SCFN lesions (18).…”

Section: Discussionmentioning

confidence: 99%