Necrosis of crestal bone related to the use of excessive formocresol medication during endodontic treatment

Cambruzzi, John V.; Greenfeld, Raymond S.

doi:10.1016/s0099-2399(83)80062-4

Cited by 20 publications

(16 citation statements)

References 11 publications

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“…In addition, a study by Nishimura et al reported that the use of formocresol caused chromosomal damage to human dental pulp cells 8. A study by Cambruzzi and Greenfeld revealed that excessive use of formocresol during root canal treatment caused bone necrosis 9. A study by Kawakam et al reported tooth exfoliation and bone necrosis caused by formocresol leakage during root canal treatment 10…”

Section: Discussionmentioning

confidence: 99%

Mandibular bone necrosis after use of paraformaldehyde-containing paste

2016

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Paraformaldehyde has been used in the past as a pulpotomy agent. However, it has a severe cytotoxic effect and may cause alveolar bone necrosis. Depulpin, a devitalizing agent containing 49% paraformaldehyde, is no longer used frequently due to its severe side effects. In the two cases described in the present study, Depulpin was used as a devitalizing agent during root canal treatment. It caused a gradual loss of sensibility in adjacent teeth, gingival necrosis, and osteomyelitis. This case report demonstrates the serious side effects of using a paraformaldehyde-containing paste as a devitalizing agent for pulp, particularly mandibular bone necrosis.

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Section: Discussionmentioning

confidence: 99%

Mandibular bone necrosis after use of paraformaldehyde-containing paste

2016

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“…Unfortunately, the superior diffusibility of these medicaments may have adverse effects. The penetration of cytotoxic vapourforming medicaments into the periodontium with undesirable consequences has been reported (Cambruzzi & Greenfeld 1983, Kopczyk et al, 1986, Formaldehydeand phenol-type medicaments have the potential to be distributed widely in the body (Pashley et al, 1980, Block et al 1983, Fager & Messer 1986, Hata et al 1989), In addition, formaldehyde-type medicaments have mutagenic and carcinogenic potential (Lewis & Chestner 1981). Sipes & Binkley (1986) reviewed the use of fonnocresol in dentistry and concluded that there was little justification for its continued application in root canal therapy.…”

Section: (I) As An Antibacterial Agent To Eliminate Any Remaining Bacmentioning

confidence: 99%

The role of intracanal medication in root canal treatment

1992

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The role of intracanal medication as a root canal dressing is re-examined. In pulpectomy and some root canal treatments, where the root canal contains vital pulp tissue, it is doubtful whether a routine intracanal medicament is needed. In infected root canals, intracanal medication has been advocated for many purposes. An intracanal medicament is used to: (i) eliminate any remaining bacteria after canal instrumentation; (ii) reduce inflammation of periapical tissues and pulp remnants; (iii) render canal contents inert and neutralize tissue debris; (iv) act as a barrier against leakage from the temporary filling; (v) help to dry persistently wet canals. However, most of the indications for intracanal medicaments are questionable. Intracanal medicaments should only be used for root canal disinfection as part of controlled asepsis in infected root canals, and their role is secondary to cleaning and shaping of the root canal. Thorough canal debridement and adequate canal preparation are more pertinent, and their importance is emphasized. Bacteriological sampling may be necessary if a tooth does not respond to treatment, to help in the choice of intracanal medicament.

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“…14,15 In the literature, we found 4 cases of gingival and bone necrosis caused by using FC in pulpotomy and root canal treatments. Cambruzzi et al 16 reported crestal bone and adjacent gingival tissue necrosis as a result of FC infiltration through the thinned dentinal wall after an excessive root canal preparation. Kawakami et al 17 reported that the leakage of FC used in pulpectomy led to exfoliation of the tooth and to surrounding alveolar bone necrosis, which was treated by sequestrectomy.…”

Section: Discussionmentioning

confidence: 99%

A Tunnel Shape Defect on Maxillary Bone After Accidental Injection of Formocresol Instead of Anesthetic Solution

Eğe

Demirkol²,

Mustafa³

et al. 2014

Journal of Craniofacial Surgery

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Accidental injection or leakages of various chemical disinfectants used during root canal preparation into adjacent tissues have been shown to have deleterious effects on surrounding tissue. Formocresol (FC) is an effective intracanal disinfectant used in endodontic procedures. However, it is known to have harmful effects into adjacent tissues. The aim of this article is to present an unusual case in which a 28-year-old male patient developed gingival and bone necrosis after the accidental injection of FC instead of local anesthetic solution for tooth extraction and to review cases in the literature where complications have occurred due to the use of FC.

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Necrosis of crestal bone related to the use of excessive formocresol medication during endodontic treatment

Cited by 20 publications

References 11 publications

Mandibular bone necrosis after use of paraformaldehyde-containing paste

Mandibular bone necrosis after use of paraformaldehyde-containing paste

The role of intracanal medication in root canal treatment

A Tunnel Shape Defect on Maxillary Bone After Accidental Injection of Formocresol Instead of Anesthetic Solution

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