Necrolytic Migratory Erythema without Glucagonoma in a Heroin-Dependent Patient

Bencini, Pier Luca; Vigo, G.P.; Caputo, R

doi:10.1159/000246789

Cited by 14 publications

(7 citation statements)

References 3 publications

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“…This is the second case occurring in association with opiate dependency and the first case where the patient was rechallenged, although the precise role of the opiates in the aetiology remains somewhat speculative 2 …”

Section: Introductionmentioning

confidence: 93%

Necrolytic migratory erythema in an opiate-dependent patient

et al. 2007

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An 18-year-old woman presented with severe features of seborrhoeic dermatitis involving her scalp. Subsequently, the toe webs and intertriginous areas became affected by an erythematous, slightly scaly and weepy rash. The groin area was most severely affected, and complicated by intermittent infections with staphylococci and herpes simplex. The patient admitted to smoking heroin and was subsequently enrolled in a methadone programme. A biopsy from the groin area showed a combination of parakeratosis and keratinocyte vacuolar changes, supporting a diagnosis of necrolytic migratory erythema (NME). On completion of methadadone withdrawal, the rash cleared. The rash returned upon recommencing methadone. NME consists of an irregular annular eruption with an erythematous crusted edge. It is often mistaken for intertrigo or seborrhoeic dermatitis. In this patient, a direct effect of heroin and methadone on the epidermal metabolism might be speculated. There could be a variant of the opiate recepter, which is especially sensitive to the effects of opiates. This is the second case occurring in association with opiate dependency and the first case where the patient was rechallenged, although the precise role of the opiates in the aetiology remains somewhat speculative.

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Section: Introductionmentioning

confidence: 93%

Necrolytic migratory erythema in an opiate-dependent patient

et al. 2007

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“…Cases of morbilliform eruptions in users have also been described, although the etiology remains indistinguishable between an adulterant or heroin itself [71]. Less commonly, glucagonoma-like syndrome of necrolytic migratory erythema as well as acanthosis nigricans have also been associated with heroin use [70,72,73].…”

Section: Heroinmentioning

confidence: 99%

Dermatologic Signs and Symptoms of Substance Abuse

Raiker¹,

Aouthmany²

2016

J Clin Exp Dermatol Res

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Various substances of abuse are known to cause specific cutaneous manifestations. In this review, we highlight the cutaneous manifestations associated with the use of cocaine, heroin, marijuana, methamphetamine, alcohol, and anabolic steroids. Cutaneous signs of tanning addiction are also discussed, as tanning bed use is a particularly relevant and growing problem in Dermatology. We also provide examples of general signs of drug abuse, including stigmata of injection drug use, vascular complications, and infectious complications. This review aims to make clinicians more aware of these signs in order to better recognize substance abuse disorders and guide effective treatment.

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“…al. berichten vom Vorliegen eines NME bei einem Heroin-abhängigen HIV-negativen 33 Jahre alten männlichen Patienten ohne Glukagonom [1].…”

Section: Laborbefundeunclassified

“…Aufgrund verschiedener Fallberichte wird die obligate Assoziation des NME mit einem Glukagon-sezernierenden Tumor des Pankreas wiederholt in Frage gestellt [1,2,7,8,11,13,15,16,19,20,21,24,26]. Während bei unserem Patienten autoptisch eine subakute Stauung der Leber sowie serologisch eine Immunität gegen das Hepatitis-A-Virus …”

Section: Laborbefundeunclassified

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Plattenepithelkarzinomassoziiertes nekrolytisches migratorisches Erythem

et al. 1999

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A 59-year-old Caucasian man suffered from persistent disseminated necrolytic skin lesions for 8 months. They failed to respond to a variety of therapeutic regimens but then cleared spontaneously within a few days. After one week an invasive squamous cell carcinoma of the hypopharynx became clinically apparent. At autopsy, the expected glucagonoma often associated with necrolytic migratory erythema was not found.

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Necrolytic Migratory Erythema without Glucagonoma in a Heroin-Dependent Patient

Cited by 14 publications

References 3 publications

Necrolytic migratory erythema in an opiate-dependent patient

Necrolytic migratory erythema in an opiate-dependent patient

Dermatologic Signs and Symptoms of Substance Abuse

Plattenepithelkarzinomassoziiertes nekrolytisches migratorisches Erythem

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