Necrobiotic Xanthogranuloma with Paraproteinemia

Bullock, John D.; Bartley, George B.; Campbell, Robert J.; Yanes, B.; Connelly, Jon P.; Funkhouser, James W.

doi:10.1016/s0161-6420(86)33605-4

Cited by 79 publications

(62 citation statements)

References 4 publications

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“…84 Deposition of the circulating immune complexes formed by the associated increased immunoglobulins has been speculated to be pathogenic of necrobiotic xanthogranuloma. 85 However, the true cause of this rare disease is unknown.…”

Section: Multicentric Reticulohistiocytosismentioning

confidence: 99%

Clinical and pathologic findings of paraneoplastic dermatoses

Chung

Moschella

Zembowicz

et al. 2006

Journal of the American Academy of Dermatology

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Section: Multicentric Reticulohistiocytosismentioning

confidence: 99%

Clinical and pathologic findings of paraneoplastic dermatoses

Chung

Moschella

Zembowicz

et al. 2006

Journal of the American Academy of Dermatology

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“…9 Others have suggested that NXG may be a fore¬ runner of lymphoproliferative disease.10 Necrobiotic xanthogranuloma is a chronic, progres¬ sive disorder with an uncertain prognosis. There is no clear first line of therapy.…”

Section: Discussionmentioning

confidence: 99%

An Unusual Granulomatous Disease in the Elderly

Fenske²

1997

Arch Dermatol

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“…It has been suggested that the paraprotein binds to lipoproteins. These complexes would be deposited in the dermis and taken up by histiocytes, leading to foam cells and a foreign body giant cell reaction [3,9]. According to another hypothesis, the paraprotein would directly bind to macrophages inducing activation and inflammation [10,11].…”

Section: Case Presentationmentioning

confidence: 99%

Necrobiotic xanthogranuloma successfully treated with autologous stem cell transplantation

et al. 2007

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Paraproteinemia can be complicated by necrobiotic xanthogranuloma. Therapeutic options for this progressive disease are limited, and there is no agreement on a single best strategy. We report the case of a patient with a massive periorbital infiltration narrowing the palpebral fissure and blinding the patient. Conventional myeloma therapy had only limited benefit in our patient. However, he was successfully treated with high-dose chemotherapy followed by autologous stem cell transplantation, rendering the patient free of symptoms. This is the first report of autologous stem cell transplantation in a patient with necrobiotic xanthogranuloma.

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Necrobiotic Xanthogranuloma with Paraproteinemia

Cited by 79 publications

References 4 publications

Clinical and pathologic findings of paraneoplastic dermatoses

Clinical and pathologic findings of paraneoplastic dermatoses

An Unusual Granulomatous Disease in the Elderly

Necrobiotic xanthogranuloma successfully treated with autologous stem cell transplantation

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