2020
DOI: 10.1097/gox.0000000000003000
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Necrobiosis Lipoidica Affecting the Leg: What Is the Best Treatment in a Patient with Very High Aesthetic Demand?

Abstract: Summary: Necrobiosis Lipoidica (NL) is a rare necrotising disorder of the skin characterized by collagen degeneration, thickening of blood vessels, and granulomatous inflammatory process. Its main clinical features are brownish-red papules and yellowish plaques with atrophic central areas. NL affects 0.3% -1.2% of the diabetic population, mostly women (female/male ratio is 3:1). Management of NL is challenging, especially for large lesions refractory to medical therapy, thus requiring surgical exci… Show more

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Cited by 7 publications
(6 citation statements)
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References 18 publications
(20 reference statements)
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“…Dressings and autolytic or enzymatic debridement are essential for adequate wound healing. 11 Hyperbaric therapy, [12][13][14][15] as well as negative pressure wound therapy, [16][17][18] can be considered a supportive treatment. (See figure, Supplemental Digital Content 1, which shows an algorithm for the complementary role of surgical debridement and close observation, http://links.lww.com/PRSGO/C658.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Dressings and autolytic or enzymatic debridement are essential for adequate wound healing. 11 Hyperbaric therapy, [12][13][14][15] as well as negative pressure wound therapy, [16][17][18] can be considered a supportive treatment. (See figure, Supplemental Digital Content 1, which shows an algorithm for the complementary role of surgical debridement and close observation, http://links.lww.com/PRSGO/C658.…”
Section: Discussionmentioning
confidence: 99%
“…After the acute phase, patients often recover with permanent sequelae and cosmetic implications, becoming of primary importance during the post healing period. The plastic surgeon allows for functional and aesthetic restoration of the injured parts using different surgical procedures such as DS, 18 skin grafts, autologous fat graft, [19][20][21] local flaps, 22 or free flaps. 23,24 In case 1, we used split-thickness skin grafts for coverage of skin defects of hands and feet.…”
Section: Discussionmentioning
confidence: 99%
“…In general, autologous bone-free flap is restricted by donor bone availability and surgical trauma. 17 , 18 Autologous tissues, such as bone grafts, have been proposed for sternal reconstruction with a significant rate of success, 19 , 20 but for smaller defects. For these reasons, we opted for titanium bars.…”
Section: Discussionmentioning
confidence: 99%
“… 23 Compared with secondary-intention healing, skin flaps show several advantages, including faster healing, better cosmetic result, and fewer medications needed. 24 , 25 Nevertheless, patients affected by COVID-19 presented poor clinical condition and, therefore, conservative management of the wounds is generally suggested. Minimal and serial debridement with secondary-intention healing allows for saving vital tissue while waiting for a precise necrotic demarcation.…”
Section: Discussionmentioning
confidence: 99%