Neck recurrence and mortality in esthesioneuroblastoma: Implications for management of the N0 neck

Abstract

N/A. Laryngoscope, 126:1373-1379, 2016.

A Population‐Based Analysis of Nodal Metastases in Esthesioneuroblastomas of the Sinonasal Tract

“…However, a thorough understanding of the lymphatic spread patterns of ENB is currently lacking, and many studies have advocated different approaches to elective treatment of the N0 neck . Studies on the incidence of lymph node metastases have varied in the literature, with earlier work reporting rates of 5% to 17% . Delayed cervical metastases have been discovered for up to 12 years after initial treatment of the primary site in up to 16% of patients .…”

“…In one retrospective review, over 40% of patients developed delayed cervical metastases after initially only undergoing local treatment . One systematic review reported a 60% mortality rate in patients with recurrence in the neck …”

“…Esthesioneuroblastoma (ENB) is a rare malignant tumor widely believed to arise from olfactory neuroepithelium that accounts for approximately 3% to 6% of neoplasms of the sinonasal vault and paranasal sinuses . Although there are no specific symptoms pointing to a diagnosis of ENB, patients most commonly present with unilateral nasal obstruction and epistaxis .…”

Volumetric analysis of olfactory neuroblastoma skull base laterality and implications on neck disease

“…Importantly, nodal spread of ONB carries significant prognostic implications for patients . Ten‐year disease‐specific survival drops from 90% to 36% for patients with cervical lymph node metastasis compared to patients with disease limited to the nasal cavity . Because of these prognostic consequences, studies have investigated the role of elective neck treatment in the clinically negative neck .…”

Assessment of frozen section margin analysis during olfactory neuroblastoma surgery

“…This neoplasm is locally aggressive and commonly involves the nasal cavity, paranasal sinuses, and cribriform plate; there also may be extension into the cranial and orbital compartments. Many patients develop neck and distant metastasis during the course of their disease …”