Neck Dissection: Indications, Extension, Operative Technique

Raffaelli, Marco; Chen, Amy Y.

doi:10.1007/978-3-030-84737-1_11

Cited by 1 publication

(1 citation statement)

References 145 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At present, neck dissection is necessary for the vast majority of OSCC patients. However, complications such as nerve damage, hematoma, vascular complications, hypoparathyroidism, chyle fistula, pneumothorax, and wound complications from surgical trauma can significantly impair patients’ postoperative quality of life 6 . A recent clinical trial discovery indicates that immunotherapy can activate anti‐tumour T cells in nearby lymph nodes, 7 leading to vibrant discussions among clinicians about the importance of preserving lymph nodes during surgical treatment.…”

Section: Introductionmentioning

confidence: 99%

Lymph node metastasis in oral squamous cell carcinoma: Where we are and where we are going

Cao

Zhong

et al. 2023

Clinical and Translational Dis

View full text Add to dashboard Cite

BackgroundOral cancer is a common malignant tumour in the head and neck region, with over 90% of cases being oral squamous cell carcinoma (OSCC). Lymph node metastasis (LNM) is a significant adverse prognostic factor in OSCC; however, the mechanism of LNM in OSCC remains unclear, while the strategies for managing cervical lymph nodes (CLNs) in OSCC continue to evolve. At present, neck dissection is necessary for the vast majority of OSCC patients, but complications of surgery can significantly impair patients’ postoperative quality of life. A recent clinical trial discovery indicates that immunotherapy can activate anti‐tumour T cells in nearby lymph nodes, leading to vibrant discussions among clinicians about the importance of preserving lymph nodes during surgical treatment.AimThis review aims to provide an overview of where we are: the current knowledge of OSCC LNM patterns and management strategies, and where we are going: prospects for clinical and basic research on the issue of OSCC LNM in the era of cancer immunotherapy.ResultWe summarize the general patterns and management strategies of OSCC LNM. The process of LNM in OSCC encompasses four stages: Preparation, Unleash, Migration, and Planting (‘PUMP’ principle). We propose adopting the ‘PRECISE’ model, an overall workflow that includes seven elements—prevention, radiology, preoperative evaluation, chemotherapy, immunotherapy, surgery, and postoperative evaluation—for neck management in OSCC, promoting personalized precision medicine augmented by neoadjuvant therapy. We further discussed recent advances in clinical and basic research on OSCC LNM and provided an outlook on future research directions.ConclusionOver the past two centuries, our understanding and management strategies of LNM in OSCC have evolved, seeking more precise and personalized approaches to reduce patient burden and enhance survival and quality of life. Further research should explore lymph nodes’ role in cancer immunotherapy and OSCC interactions, leading to better, less invasive treatments and improved outcomes.

show abstract

Section: Introductionmentioning

confidence: 99%