Neck Dissection in Relation With Disease-Free, Disease-Specific, and Overall Survival of Patients With Squamous Cell Cancer of the Oral Cavity

Koloutsos, Georgios; Vahtsevanos, Konstantinos; Kyrgidis, Athanassios; Kechagias, Nikolaos; Triaridis, Stefanos; Αντωνιάδης, Κωνσταντίνος

doi:10.1097/scs.0000000000001023

Cited by 12 publications

(21 citation statements)

References 23 publications

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“…In our study, the false positive rate for clinical assessment of the neck node was 35.1% and the false negative rate was 18.9%. The false positive rate in our study was slightly higher than the study by Giorgios et al (2014) that reported 28.4% false positive rate of their clinical assessment 13 . In another study by Moore et al (1986), they suggested that false-positive preoperative assessments are more likely in patients with large tumours because of the examiner's expectation of metastatic nodes and the increased likelihood of reactive nodal hyperplasia due to local factors 14 .…”

Section: Residual and Recurrent Neck Diseasescontrasting

confidence: 82%

“…In our study, positive likelihood ratio of 1.71 indicates that cases with clinically positive neck (cN+) have more than 1.7-fold odds of having a pathologically positive neck node (pN+) and those with clinically N0 neck have 4 times less odds of a pathologically positive neck node (pN+) with a negative likelihood ratio of 0.22. The accuracy of pre-operative clinical assessment relied on clinical skills of the examiner, the patients' body structure, the patients' co-operativeness and history of previous surgery or radiotherapy treatment 13 Another important finding from this study was the predictive rate for risk of occult nodal metastasis for the malignant tumours of the oral cavity. The rate for occult nodal metastasis for malignant tumours of the oral cavity was 22.5%.…”

Section: Residual and Recurrent Neck Diseasesmentioning

confidence: 92%

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Neck dissection for head and neck malignancies: A Malaysian 13 years review

Hishamuddin

Azman

Kong

et al. 2017

Bangladesh J Med Sci

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Introduction and Objective: Neck dissection (ND) is a surgical procedure performed in treating head and neck cancer patients with cervical neck metastasis. The aim of neck dissection is to achieveloco-regional control thus optimizing the cancer's cure rate. Various complications may potentially occur following this surgery. The main objective of this study is to evaluate the incidence of complications following neck dissection. Materials & Methods: This is a 13 years retrospective descriptive case notes analysis conducted in UKMMC (University Kebangsaan Malaysia Medical Centre), a tertiary centre in Malaysia. Neck dissection surgeries that were performed between January 2000tillDecember 2012 were recruited for data analyses. Results: A total of 233 neck dissections were performed in our centre over 13 years period from January 2000 until December 2012. Of these, 27 cases were excluded due to unavailability of data and therefore a total of 206 cases were recruited for data analyses.The types of neck dissection performed include Extended Radical ND (n=7), Radical ND (n=40), Modified Radical ND (n=88) and Selective ND (n=71). Majority of neck dissection was performed for malignant oral cavity tumours (47.1%). Out of 206 cases, 57 (27.7%) developed wound complications, 48 (23.3%) cases had nerve complications with marginal mandibular nerve was most commonly injured (13%) and 20 (9.7%) cases had vascular and lymphatic complications mainly involving the thoracic duct (5.3%). The incidence of residual or recurrent neck disease was observed in 41 cases (20%). Pre-operative clinical assesment of cervical neck node metastatic status has a high sensivity of 89.7% but low specificity of 47.5%. Conclusion: Various complications may potentially occur following neck dissection. Awareness of these possible complications could minimize the incidence of complication following this surgery. This current study observed a strong association between the type of neck dissection performed with the incidence of wound, nerve and vascularcomplications following neck dissection surgery.

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Section: Residual and Recurrent Neck Diseasescontrasting

confidence: 82%

Section: Residual and Recurrent Neck Diseasesmentioning

confidence: 92%

Neck dissection for head and neck malignancies: A Malaysian 13 years review

Hishamuddin

Azman

Kong

et al. 2017

Bangladesh J Med Sci

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“…1,2 Despite advances in treatment and reconstruction, mortality continues to remain high for oral cavity SCCA due to significant occurrence of distant metastasis and metachronous malignancies. [2][3][4] Oral cavity SCCA has a high risk of cervical metastasis, with up to 50% of patients having pathologically positive regional disease at the time of diagnosis. 4 Nonmelanoma skin cancer is the most commonly diagnosed malignancy, and its incidence increases as the population ages.…”

Section: Introductionmentioning

confidence: 99%

Minimum lymph node yield in elective level I–III neck dissection

et al. 2017

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“…The recurrence rate of oral cancer has been reported to be as high as 35% (Hsieh et al, 2012). In spite of the progress obtained in comprehensive treatment strategies such as surgery, radiotherapy, and chemotherapy, the survival and prognosis of oral cancer appear to be disappointing with lower survival rates in patients with lymph node metastasis (Koloutsos et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Although there have been significant developments in comprehensive treatment strategies such as surgery, radiotherapy, and chemotherapy, the prognosis remains poor. Insitu recurrence, neck metastasis and recurrence, and distant metastasis are important factors affecting survival and prognosis (Koloutsos et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

MiR-214 regulates oral cancer KB cell apoptosis through targeting RASSF5

Yin

Chen

et al. 2017

Genet. Mol. Res.

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ABSTRACT. Ras association domain family member 5 (RASSF5), a member of the Ras association domain family, induces cell apoptosis by phosphorylating FOXO3a, which triggers target gene BIM (proapoptotic factor) activation. MiR-214 is overexpressed in oral cancer tissue, indicating its possible involvement in oral cancer pathogenesis. Bioinformatics analysis has revealed a complimentary sequence between miR-214 and the 3'-UTR of RASSF5 mRNA. However, whether miR-124 regulates RASSF5 in oral cancer remains poorly understood. We aimed to investigate the role of miR-214 in RASSF5 expression regulation in oral cancer. Tumor and paracarcinoma tissues were obtained from 48 oral cancer patients to examine miR-214 and RASSF5 expression. The relationship between miR-214 and RASSF5 was investigated by dual luciferase reporter gene assay. Oral cancer KB cells were cultured in vitro and divided into inhibitor NC, miR-214 inhibitor, Scramble-pMD18, RASSF5-pMD18, and miR-214 inhibitor + RASSF5-pMD18 groups. Caspase 3 activity, cell apoptosis, and total protein expression were measured by spectrophotometry, flow cytometry, and western blot, respectively. MiR-214 expression was significantly increased, while that of RASSF5 decreased in oral cancer tumor tissues compared to paracarcinoma tissues. Luciferase assay showed that miR-214 suppressed RASSF5 expression by targeting its 3'-UTR. Down-regulation of miR-214 and/or enhancement of RASSF5 expression markedly increased FOXO3a phosphorylation, BIM expression, caspase 3 activity, and apoptosis. In conclusion, miR-214 expression was elevated and RASSF5 was down-regulated in oral cancer. Moreover, miR-214 regulated KB cell apoptosis through targeted inhibition of RASSF5 expression, FOXO3a phosphorylation, and BIM expression, suggesting its possible application as a novel therapeutic oral cancer target.

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Neck Dissection in Relation With Disease-Free, Disease-Specific, and Overall Survival of Patients With Squamous Cell Cancer of the Oral Cavity

Abstract: No means of presurgical assessment either clinical or imaging was sufficiently sensitive and specific enough to predict the metastatic status of the neck. An approximately 50% decrease in the 5-year overall survival rate may be expected when regional metastasis is confirmed.

Cited by 12 publications

References 23 publications

Neck dissection for head and neck malignancies: A Malaysian 13 years review

Neck dissection for head and neck malignancies: A Malaysian 13 years review

Minimum lymph node yield in elective level I–III neck dissection

MiR-214 regulates oral cancer KB cell apoptosis through targeting RASSF5

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