Neck Disability and Swallowing Function in Posttreatment Head and Neck Cancer Patients

Harris, Alexandria; Lyu, Lingyun; Wasserman-Winko, Tamara; George, Sam; Johnson, Jonas T.; Nilsen, Marci Lee

doi:10.1177/0194599820923630

Cited by 11 publications

(19 citation statements)

References 73 publications

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“…The sampling device was powered by two sources, a 5 V source and a 24 V source (1). Air to purge the sampling chamber was supplied by a membrane pump (4) and passed through a filter filled with a mixture of zeolite and silica gel (3). Figure 2 shows the generalized structure of the gas analytical system for the bag sampling mode.…”

Section: Diagnostics 2020 10 X For Peer Review 5 Of 11mentioning

confidence: 99%

“…The bottom valve (2) is for the timely supply of the gas sample. The upper two valves (1,3) are used to purge the chamber with a pump. The sensors operate in a thermal cycling mode of 3.5 s of heating and 5.5 s of cooling.…”

Section: Diagnostics 2020 10 X For Peer Review 5 Of 11mentioning

confidence: 99%

“…Treatment of patients with locally advanced malignant tumors of the oropharyngeal region and larynx is often associated with a whole complex of negative consequences: disability, impaired physiological functions, severe cosmetic losses and the occurrence of psycho-emotional trauma [3]. This circumstance directs clinical oncologists and specialists in related fields to search for affordable and effective methods for diagnosing malignant tumors at early stages, which reflects modern principles of screening methods for diagnosing tumors of the oropharyngeal region and larynx -reproducibility, low cost, independence from the human factor (reduction of error), and the possibility of use in non-specialized clinics by primary care physicians (therapists, ENT doctors, dentists) [4].…”

Section: Introductionmentioning

confidence: 99%

“…At the moment of transition from the heating phase to the cooling phase of the sensors (Figure 3-mark 5000 ms), valves (2) and (3) open for exactly one second. The same opening time is used for valves (2) and 3, and the weight of the load on the bag provides the same volume of gas sample (~250 mL) introduced into the 1 L sampling chamber.…”

mentioning

confidence: 99%

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Cancer Diagnosis by Neural Network Analysis of Data from Semiconductor Sensors

et al. 2020

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“Electronic nose” technology, including technical and software tools to analyze gas mixtures, is promising regarding the diagnosis of malignant neoplasms. This paper presents the research results of breath samples analysis from 59 people, including patients with a confirmed diagnosis of respiratory tract cancer. The research was carried out using a gas analytical system including a sampling device with 14 metal oxide sensors and a computer for data analysis. After digitization and preprocessing, the data were analyzed by a neural network with perceptron architecture. As a result, the accuracy of determining oncological disease was 81.85%, the sensitivity was 90.73%, and the specificity was 61.39%.

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Section: Diagnostics 2020 10 X For Peer Review 5 Of 11mentioning

confidence: 99%

Section: Diagnostics 2020 10 X For Peer Review 5 Of 11mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Cancer Diagnosis by Neural Network Analysis of Data from Semiconductor Sensors

et al. 2020

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“…The recommended diagnostic methods are aimed at the timely detection of tumor processes in the early stages, and effective treatment, in order to achieve good clinical results, which, due to the above-mentioned shortcomings, are not readily achievable. In the treatment of patients with locally advanced cancers of the oropharyngeal region and larynx, a whole complex of negative consequences is often presented, such as disability, physiological dysfunction, severe cosmetic damage, and the development of psychoemotional trauma [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Non-Invasive Diagnosis of Malignancies Based on the Analysis of Markers in Exhaled Air

et al. 2020

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Novel non-invasive methods for the diagnosis of malignancies should be effective for early diagnosis, reproducible, inexpensive, and independent from the human factor. Our aim was to establish the applicability of the non-invasive method, based on the analysis of air exhaled by patients who are at different stages of oropharyngeal, larynx and lung cancer. The diagnostic device includes semiconductor sensors capable of measuring the concentrations of gas components in exhaled air, with the high sensitivity of 1 ppm. The neural network uses signals from these sensors to perform classification and identify cancer patients. Prior to the diagnostic procedure of the non-invasive method, we clarified the extent and stage of the tumor according to current international standards and recommendations for the diagnosis of malignancies. The statistical dataset for neural network training and method validation included samples from 121 patients with the most common tumor localizations (lungs, oropharyngeal region and larynx). The largest number of cases (21 patients) were lung cancer, while the number of patients with oropharyngeal or laryngeal cancer varied from 1 to 9, depending on tumor localization (oropharyngeal, tongue, oral cavity, larynx and mucosa of the lower jaw). In the case of lung cancer, the parameters of the diagnostic device are determined as follows: sensitivity—95.24%, specificity—76.19%. For oropharyngeal cancer and laryngeal cancer, these parameters were 67.74% and 87.1%, respectively. This non-invasive method could lead to relevant medicinal findings and provide an opportunity for clinical utility and patient benefit upon early diagnosis of malignancies.

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Quantifying Total and Out-of-Pocket Costs Associated With Head and Neck Cancer Survivorship

Chidambaram

Luong

Graboyes

et al. 2022

JAMA Otolaryngol Head Neck Surg

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ImportanceOncologic treatment is costly to the health care system and to individuals, but patients with head and neck cancer (HNC) also have long-term care needs after treatment. Survivors of HNC require specific consideration given their rapidly growing numbers. This subpopulation of cancer survivors often experiences long-term treatment-associated morbidity.ObjectiveTo describe the total and out-of-pocket (OOP) costs associated with HNC survivorship and the risk factors for financial toxicity among this population.Design, Setting, and ParticipantsThis was a retrospective review and economic evaluation of a cohort of US adults with a diagnosis of HNC from 2006 to 2018. The study used data the from IBM MarketScan Commercial Claims Database. Data were analyzed from November 2020 to June 2022.ExposuresTreatment for HNC.Main Outcomes and MeasuresTotal and OOP medical costs were assessed monthly and reported relative to the date of HNC diagnosis. The primary outcome was the difference between a patient’s mean monthly survivorship costs (13-60 months after diagnosis) and mean monthly baseline costs (7-12 months before diagnosis). Univariate and multivariable linear regression models were created for total and OOP costs to generate coefficient estimates with 95% CIs.ResultsThe study cohort of this economic evaluation included 19 098 patients with HNC (median [range] age, 56 [18-64] years; 14 144 [74.1%] men and 4954 [25.9%] women; race and ethnicity were not considered). Throughout the survivorship period, median total and OOP costs were $372 per month and $31 per month higher than baseline costs, respectively, with variation in expenses by demographic information, health plan type, and oncologic variables. In the multivariable model, greater total and OOP excess survivorship costs were associated with female sex ($343/mo; 95% CI, $126 to $560 and $9/mo; 95% CI, $4 to $14). Highest and lowest total excess survivorship costs associated with cancer site were seen for hypopharyngeal ($1908/mo; 95% CI, $1102 to $2714) and oropharyngeal cancers (−$703/mo; 95% CI, −$967 to −$439) vs oral cavity cancers. Compared with surgery or radiation therapy alone, multimodal treatment was generally associated with excess OOP survivorship costs.Conclusions and RelevanceThe findings of this retrospective economic evaluation review suggest that the costs of HNC survivorship remain persistently elevated above baseline costs for at least 5 years after diagnosis. High survivorship costs were associated with female sex, hypopharyngeal tumors, and treatment with multimodal therapy. Practitioners should seek to minimize costs for these patients at higher-risk of financial toxicity after treatment and work to provide directed supportive services.

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Neck Disability and Swallowing Function in Posttreatment Head and Neck Cancer Patients

Cited by 11 publications

References 73 publications

Cancer Diagnosis by Neural Network Analysis of Data from Semiconductor Sensors

Cancer Diagnosis by Neural Network Analysis of Data from Semiconductor Sensors

Non-Invasive Diagnosis of Malignancies Based on the Analysis of Markers in Exhaled Air

Quantifying Total and Out-of-Pocket Costs Associated With Head and Neck Cancer Survivorship

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