Neck circumference is a good predictor for insulin resistance in women with polycystic ovary syndrome

Abstract

Objective: To assess the role of neck circumference (NC) in assessing insulin resistance (IR) in polycystic ovary syndrome (PCOS). Design: A cross-sectional study. Setting: University-affiliated hospital. Patient(s): One hundred forty-three women with PCOS were recruited from November 2018 to February 2020. Intervention(s): None. Main Outcome Measure(s): The associations of NC with IR and the cutoff points of NC for IR. Result(s): The prevalence rates of IR were 64.3%. The patients with PCOS with IR had significantly greater values of systolic blood pressure, NC, body mass index, waist-to-hip ratio, waist circumference, fasting blood glucose, fasting insulin, and homeostasis model assessment of insulin resistance (HOMA-IR). Pearson correlation analysis showed body mass index (log-transformed), waist circumference, waist-to-hip ratio, and HOMA-IR (log-transformed) were positively correlated with NC. Multivariable linear regression showed that NC was significantly associated with HOMA-IR (log-transformed), with the standardized regression coefficient of 0.330 with adjustment for potential confounding factors. Furthermore, multivariate logistic regression analyses showed NC was associated significantly with increased risk of IR, with the adjusted odds ratio of 1.423. Additionally, NC was able to identify IR in women with PCOS; the optimal cut-off points was 34.3 cm (Youden index ¼ 0.586). Conclusion(s):Neck circumference is positively associated with IR in women with PCOS. We suggest NC as a novel, simple, practical, and reliable anthropometric measure to be used to predict the risk of IR in patients with PCOS. (Fertil Steril Ò 2021;115:753-60. Ó2020 by American Society for Reproductive Medicine.) El resumen está disponible en Español al final del artículo.

Neck Circumference Is a Reliable Predictor for Hyperuricemia in Women With Polycystic Ovary Syndrome: a Case Control Study

“…Several potential mechanisms account for the high prevalence of hyperuricemia in women with PCOS and larger NCs. First, recent compelling evidence indicates that in women with PCOS, NC is a good predictor for insulin resistance (IR) (40), which consequently increases the risk of hyperuricemia by reducing the excretion of uric acid through increased proximal tubular sodium reabsorption(26, 41).…”

Visceral adiposity index was independently associated with hyperuricemia in patients with polycystic ovary syndrome

“…Of 318 PCOS patients, a total of 256 (80.5%) with serum urate data were left for further analysis. The diagnosis of PCOS is based on Rotterdam criteria [18], which has been detailed described in our previous report [19]. The ethics committee of the First A liated Hospital of Xiamen Medical University approved this study protocol and written informed consent was obtained from each participant.…”

“…The socio-demographic status included age, medical history and drug use, smoking and drinking, etc. All clinical, anthropometric and laboratory indicators were measured by a properly trained healthcare workers following standardized protocols and performed as described in the previous report [19]. Height, WC, Hip circumference (HC) and body weight were measured by using a calibrated scale with lightweight clothing.…”

Visceral Adiposity Index was Independently Associated with Hyperuricemia in Patients with Polycystic Ovary Syndrome

“…Of 318 PCOS patients, a total of 256 (80.5%) with serum urate data were left for further analysis. The diagnosis of PCOS is based on Rotterdam criteria [18], which has been detailed described in our previous report [19]. The ethics committee of the First A liated Hospital of Xiamen Medical University approved this study protocol and written informed consent was obtained from each participant.…”