“…Thus, the PRB effect could largely originate from baroreflex driven CVA increments via shared (i.e., intra-thoracic pressure modulations) as well as distinct pathways compared to loaded RB (Gholamrezaei et al, 2019(Gholamrezaei et al, , 2021a. Hence, «loaded PRB» might indeed generate additional increments on baroreflex mediated CVA, as indicated by dose-dependent responses to mechanical stimulation (i.e., neck chamber), which however could be limited due to a potential ceiling effect (Seredyński et al, 2021). However, as the hypothesized superimposed CVA boost could rely on the non-baroreflex mediated contribution of pulmonary afferents, the loaded PRB hypothesis might as well be falsified, warranting within-subjects design studies comparing the respective techniques (Baden et al, 2014).…”