Neck and Vulvar Papules in an 8-Year-Old Girl

Trager, Jonathan D.K.; Silvers, Jack; Reed, Jon A.; Scott, Rachelle A.

doi:10.1001/archderm.135.2.203

Cited by 16 publications

(13 citation statements)

References 19 publications

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“…On the other hand, negativity has also previously been obtained in shorter series of syringomas,5-7 and even ourselves have seen negativity in an eruptive variant of syringoma that we reported 8…”

supporting

confidence: 79%

Cutaneous Syringoma: the Status of Hormonal Receptors

Fernández-Flores

2008

Yonsei Med J

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supporting

confidence: 79%

Cutaneous Syringoma: the Status of Hormonal Receptors

Fernández-Flores

2008

Yonsei Med J

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“…The differential diagnosis of vulvar syringoma includes Fox-Fordyces disease, epidermal cysts, lichen simplex chronicus, and steatocystoma multiplex 8. Clinical impressions in our study were syringoma in 42 cases with concordance rate of 68.9%, verruca plana in 9 cases and other various diseases including bowenoid papulosis, keratosis pilaris, sarcoidosis, xanthelasma and sebaceous hyperplasia.…”

Section: Discussionmentioning

confidence: 48%

“…However, there have been reports in which increase in ER and PR cannot be demonstrated. Trager et al8 reported a case of syringoma showing neck and vulvar papules in an 8-year-old girl with negative results for both ER and PR by immunohistochemical stains. Recently, Huang et al6 reported that all 15 specimens failed to stain with the ER and PR markers on syringoma and peripheral normal vulvar tissue.…”

Section: Discussionmentioning

confidence: 99%

Syringoma: A Clinicopathologic and Immunohistologic Study and Results of Treatment

Chang

Lee

2007

Yonsei Med J

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The purpose of our study was to describe clinical and histopathological features of sixty one patients with histological diagnosis of syringoma over four year period in our dermatology clinic in Korea. Female:male ratio was 6.6:1 with onset of age during 2nd and 3rd decades in more than half of the patients in our study. The most frequently involved site was eyelids (43 cases, 70.5%) and the most common color of lesion was skin-color (30 cases, 49.2%). In 34 cases, characteristic tad-pole appearances (55.7%) were observed. Basal hyperpigmentation was observed more frequently in brown-colored lesion (p = 0.005). Fibrosis was observed more frequently in erythematous lesion (p = 0.033). Keratin cyst was observed less frequently in genital involved group (p = 0.006). We also performed immunohistochemical stain for the presence of progesterone receptor (PR) and estrogen receptor (ER) in fifty six cases with negative results.

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“…55 Since then, isolated cases and small case series of syringomas involving the genital region have been reported. [54][55][56][57][58][59][60][61][62][63][64][65][66][67] In a Taiwanese series of 18 cases of vulvar syringoma, lesions were most common in women during the third decade, most often (11 of 18; 61%) presenting as multiple, flesh-colored or brownish papules on the labia majora. 54 Three (17%) presented with discrete, whitish cystic papules.…”

mentioning

confidence: 99%

“…54 Although some researchers have hypothesized the development of syringoma to be under hormonal influence, 56,57 no studies to date have demonstrated staining for estrogen receptor or progesterone receptor, to our knowledge. 54,58 Of interest, autoimmune acrosyringitis has been proposed as a cause of eruptive syringoma in a case report. 59 Reported effective treatment options for vulvar syringomas include carbon dioxide laser treatment, 54,60 cryotherapy, 61 electrosurgery, 62 and excision.…”

mentioning

confidence: 99%

Vulvar Adnexal Lesions: A 32-Year, Single-Institution Review From Massachusetts General Hospital

Baker

Selim

Hoang

2013

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Because the skin and modified mucosal surfaces of the vulvar region contain dense apocrine glands and anogenital mammary-like glands, in addition to eccrine glands and folliculosebaceous units, benign as well as malignant lesions derived from these adnexal structures are, not surprisingly, found in the vulva. However, their incidence occurring in the vulva has not been reported, to our knowledge.Objective.-To determine the incidence of various vulvar adnexal lesions.Design.-We performed a retrospective review of the cases at our institution.Results.-A total of 189 vulvar adnexal lesions were identified. Most of these lesions were benign (133 of 189; 70%), with hidradenoma papilliferum being the most common, followed by syringoma and various types of cysts. Rare cases of tubular adenoma, poroma, spiradenoma, hidradenoma, cylindroma, sebaceoma, and trichoepithelioma were identified. Malignant adnexal neoplasms comprised the remaining 30% (56 of 189) of the cases. Extramammary Paget disease was the most common (49 of 56), and 29% (14 of 49) demonstrated an invasive component. Rare cases of basal cell carcinoma, sebaceous carcinoma, apocrine carcinoma, adenoid cystic carcinoma, and spiradenocarcinoma were identified.Conclusions.-In this retrospective review, we identified several benign entities that have not been previously reported on the vulva, namely pilomatricoma, poroma, spiradenoma, and sebaceoma. Hidradenoma papilliferum and extramammary Paget disease were the most common benign and malignant adnexal neoplasms, respectively. The spectrum of various vulvar adnexal lesions appears to reflect the frequency of the underlying glandular elements.

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Neck and Vulvar Papules in an 8-Year-Old Girl

Cited by 16 publications

References 19 publications

Cutaneous Syringoma: the Status of Hormonal Receptors

Cutaneous Syringoma: the Status of Hormonal Receptors

Syringoma: A Clinicopathologic and Immunohistologic Study and Results of Treatment

Vulvar Adnexal Lesions: A 32-Year, Single-Institution Review From Massachusetts General Hospital

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