Necessity of establishing a background microbial library in different medical institutions for the diagnosis of periprosthetic infection using metagenomic next-generation sequencing: Data-Based Analysis
Abstract:Background Due to the extremely high sensitivity of metagenomic next-generation sequencing (mNGS) testing, even a small amount of nucleic acid fragments exposed during sampling or testing may lead to false positives, which is one of the biggest challenges in interpreting mNGS testing reports. In this study, for the first time, we experimentally detected and established Periprosthetic joint infection (PJI)-related interfering nucleic acid background microbial libraries (BML) in different medical institutions to… Show more
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