Nebulized Magnesium Sulfate in Acute Bronchiolitis: A Randomized Controlled Trial

Abstract

Thus, in infants with acute bronchiolitis, the effect of nebulized magnesium sulfate is comparable to nebulized epinephrine. However nebulized magnesium sulfate can improve the clinical score so it may have additive effect to reduce symptoms during hospitalization.

RETRACTED: Effect of magnesium on arrhythmia incidence in patients undergoing coronary artery bypass grafting

“…MGS inhibits the release of catecholamines from adrenal medulla and peripheral nerve endings and directly blocks receptors of catecholamines . Therefore, MGS causes sympathetic block which causes dilated blood vessels and, consequently, reduces blood pressure .…”

IV Magnesium Sulfate for Bronchiolitis

“…Nebulized magnesium has been tested in bronchiolitis; in a previous multicenter study report, nebulized magnesium sulfate with epinephrine was compared with nebulized epinephrine in infants with moderate to severe bronchiolitis, but patients with previous repeated courses of steroids or bronchodilators and/or family history of asthma were excluded. 21 Although there was significant improvement in respiratory distress assessment scores in the second and third day after admission favoring nebulized magnesium, no difference was found in the length of stay or need for oxygen. In a second small trial that enrolled patients with moderate bronchiolitis and compared nebulized magnesium, nebulized salbutamol, and nebulized magnesium sulfate/salbutamol combined, the only significant difference was the Wang severity score at 4 h, which favored the combined aerosol group compared with the nebulized magnesium alone group (P < .05).…”

Magnesium sulfate in pediatric anesthesia: the Super Adjuvant

“…Tracheal intubation (IV) (31) 30 mgÁkg À1 Laryngospasm (IV) (23,33,34) 15 mgÁkg À1 Bronchospasm (IV) (36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46) 50-100 mgÁkg À1 + 40-50 mgÁkg À1 Áh À1 Bronchospasm (nebulized) (47)(48)(49)(50)(51)(52)(53)(54)(55) 40 mgÁkg À1 or 150 mg (total dose) Antiadrenergic response Cardiopulmonary bypass (IV) (57-60) 25-50 mgÁkg À1 Long QT syndrome (IV) (61) 30-50 mgÁkg À1 + 5-20 mgÁkg À1 Áh À1 Neonatal pulmonary hypertension (IV) (63) 200 mgÁkg À1 + 20-150 mgÁkg À1 Áh À1 Pheocromocytoma (IV) (64) 30-50 mgÁkg À1 + 5-20 mgÁkg À1 Áh À1 Organ protection Neuroprotection (IV) (68-72) 250 mgÁkg À1 Áday À1 Myocardial protection (cardioplegia) (73,74) 40-80 mgÁkg À1 Hypomagnesemia Perioperative hypomagnesemia (IV) (58,59) 25-50 mgÁkg À1 AE 5-20 mgÁkg À1 Áh À1 alveolar concentration by 50% and the induction dose of propofol; it shortens the latency time until a bispectral index value <60 is reached; and it reduces ventilation requirements (tidal volume and respiratory rate) as metabolism decreases (O 2 consumption and CO 2 production) (2,6). Sevoflurane has certain excitatory effects on the central nervous system, which may be associated with increased seizure activity in children.…”

“…Although more studies are needed in this line, current results suggest favorable cost-effectiveness; better side effect profile than IV MgSO 4 ; greater response in severe crisis and early treatment; and comparable efficacy to nebulized epinephrine, lower than nebulized beta-2 agonists and IV MgSO 4 , and higher when it is associated with nebulized beta-2 agonist. The recommended dosing regimen for nebulized MgSO 4 is 40 mgÁkg À1 or a total dose of 150 mg (47)(48)(49)(50)(51)(52)(53)(54)(55).…”