Nebulized hypertonic saline in infants hospitalized with moderately severe bronchiolitis due to RSV infection: A multicenter randomized controlled trial

Abstract

Nebulized HS therapy did not significantly reduce LOS among infants with bronchiolitis due to RSV.

Hypertonic saline: Not useful in infant bronchiolitis?

“…The mean (±SD) length of stay (LOS) in hospital was quite similar in the HS (4.81 ± 2.14 days) and NS (4.61 ± 2.18 days) groups. The duration of oxygen administration and the improvement of clinical severity scores from baseline to 72 h showed no significant differences between the treatment groups . The negative result of the study that is no association between saline inhalations and recovery from bronchiolitis was confirmed with survival and multivariate analyses.…”

“…The negative result of the study that is no association between saline inhalations and recovery from bronchiolitis was confirmed with survival and multivariate analyses. The conclusions were similarly negative in ad hoc subgroup analyses performed between groups constructed on the basis of disease severity …”

“…Since NS inhalations may influence the course of bronchiolitis, either accelerating or more probably delaying recovery, controls should be infants with bronchiolitis treated with standard therapy without any inhalations, but also in this kind of design, the clinical assessment should happen blind. As Morikawa et al concluded, there is no research‐based evidence for a routine use of saline inhalations in infants with bronchiolitis.…”

Nebulised hypertonic saline in children with bronchiolitis admitted to the paediatric intensive care unit: A retrospective study

“…Likewise, a more recent RCT by Morikawa et al . failed to detect a difference in LOS between HS and NS …”

Pediatric Pulmonology year in review 2018: Asthma, physiology/pulmonary function testing, and respiratory infections

“…A meta‐analysis carried out by Zhang et al suggested that when used in the emergency department setting in combination with bronchodilators, inhaled hypertonic saline may help reduce the risk for the hospital admission. However, Morikawa et al reported results of an open‐label multicenter randomized controlled trial comparing outcomes in 128 infants hospitalized with RSV bronchiolitis treated with either 3% hypertonic saline or normal saline and found no effect on length of hospital stay.…”