Nebulised interferon beta-1a (SNG001) in the treatment of viral exacerbations of COPD
Phillip D. Monk,
Jody L. Brookes,
Victoria J. Tear
et al.
Abstract:Background
Respiratory viral infections are major drivers of chronic obstructive pulmonary disease (COPD) exacerbations. Interferon-β is naturally produced in response to viral infection, limiting replication. This exploratory study aimed to demonstrate proof-of-mechanism, and evaluate the efficacy and safety of inhaled recombinant interferon-β1a (SNG001) in COPD. Part 1 assessed the effects of SNG001 on induced sputum antiviral interferon-stimulated gene expression, sputum differential cell co… Show more
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