Nebivolol prevents vascular oxidative stress and hypertension in rats chronically treated with ethanol

Vale, Gabriel Tavares do; Simplicio, Janaina A.; Gonzaga, Natália A.; Yokota, Rodrigo; Ribeiro, Amanda Aparecida; Casarini, Dulce Elena; Martinis, Bruno Spinosa De; Tirapelli, Carlos Renato

doi:10.1016/j.atherosclerosis.2018.04.041

Cited by 23 publications

(21 citation statements)

References 47 publications

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“…Similarly and parallel to the results reported by previous studies, we observed higher MDA levels after the I/R injury in the ovarian tissue in the I/R group compared to the control group in this study. In addition, MDA levels were found lower in the NEB‐treated groups parallel to the findings of previous studies providing evidence for the antioxidant effects of NEB 27,28 …”

Section: Discussionsupporting

confidence: 88%

“…In addition, MDA levels were found lower in the NEB-treated groups parallel to the findings of previous studies providing evidence for the antioxidant effects of NEB. 27,28 We selected GSH as the parameter to demonstrate the antioxidant effects investigated in this study. GSH is the major antioxidant that mitigates and prevents cellular injury occurring due to oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

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Protective effects of nebivolol on ovarian ischemia–reperfusion injury in rat

Çolak

Gürlek

Topçu

et al. 2020

J of Obstet and Gynaecol

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Aim: Ovarian torsion is a common gynecological emergency of reproductive ages, occurring at rates of 2.7-7.4%. This study aimed to evaluate the antioxidant effects of Nebivolol (NEB) and histopathological changes in experimental ischemic (I) and ischemic-reperfusion (I/R) injury in rat ovaries. Methods: Forty-eight adult female rats were randomly separated into six groups as group 1 (control) receiving an oral saline solution for 3 days; group 2 (I) that underwent ischemia for 3 h with the application of atraumatic vascular clips; group 3 (I/R); group 4 (I + NEB) receiving 10 mg/kg NEB by oral gavage 30 min prior to the ischemia induction; group 5 (I/R + NEB) receiving 10 mg/kg NEB, and group 6 (control + NEB) receiving oral 10 mg/kg NEB for 3 days before ischemia induction followed by consequent reperfusion. Ovarian tissue damage was scored by histopathological analysis. Ovarian tissue malondialdehyde (MDA) and glutathione (GSH) levels were measured biochemically. Results: The levels of MDA and tumor necrosis factor-alpha (TNF-α), and TUNEL assay positivity scores increased in the I and I/R groups. GSH levels decreased in all case groups (P < 0.05). The oral administration of NEB (10 mg/kg) to the I-and I/R-groups reduced the levels of MDA and TNF-α and TUNEL assay immunopositivity scores (P < 0.05). GSH levels increased in the treatment groups. Conclusion: The current experimental ovarian torsion study suggests a protective role for NEB against I and I/R injury in rat ovaries. NEB may be a novel agent for decreasing ovarian I/R injury.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Protective effects of nebivolol on ovarian ischemia–reperfusion injury in rat

Çolak

Gürlek

Topçu

et al. 2020

J of Obstet and Gynaecol

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“…Other potential mechanisms by which ethanol causes cardiovascular changes include increased ROS, reduced antioxidant defense, apoptotic cell death, mitochondrial stress, abnormalities in fatty acid metabolism and transport, and accelerated protein catabolism (10,36). In the cardiovascular system, specifically, ethanol consumption increases oxidative stress, decreases nitric oxide (NO) bioavailability, stimulates the renin-angiotensin-aldosterone system (RAAS), increases sympathetic nervous system activity, causes insulin resistance, stimulates the hypothalamic-pituitary axis (HPA) with cortisol excess, alters Ca 2 þ -Mg 2 þ handling, and stimulates the endothelin-1 system (10,(37)(38)(39)(40)(41)(42). These processes may individually and synergistically contribute to cardiovascular remodeling and dysfunction, myocardial and vascular oxidative/nitrosative stress, vascular hyperresponsiveness, endothelial dysfunction, and vascular inflammation observed with excessive ethanol consumption (10,38,(41)(42)(43).…”

Section: Potential Mechanisms Underlying Cardiovascular Dysfunction Induced By Ethanolmentioning

confidence: 99%

“…In addition, the infiltration of immune cells in the PVAT contributes to the low-grade inflammation seen in multiple CVD (157). Ethanol affects the modulatory effects of PVAT on vascular function (40,54). However, despite studies showing that both ethanol consumption and gut microbiota activate the immune system, and overactivation of the immune system is linked to cardiovascular dysfunction, the mechanisms underlying these events are not fully understood.…”

Section: The Immune Systemmentioning

confidence: 99%

Ethanol: striking the cardiovascular system by harming the gut microbiota

Silva

Elias-Oliveira

McCarthy

et al. 2021

American Journal of Physiology-Heart and Circulatory Physiology

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Ethanol consumption represents a significant public health problem, and excessive ethanol intake is a risk factor for cardiovascular disease (CVD), one of the leading causes of death and disability worldwide. The mechanisms underlying the effects of ethanol on the cardiovascular system are complex and not fully comprehended. The gut microbiota and their metabolites are indispensable symbionts essential for health and homeostasis and therefore, have emerged as potential contributors to ethanol-induced cardiovascular system dysfunction. By mechanisms that are not completely understood, the gut microbiota modulates the immune system and activates several signaling pathways that stimulate inflammatory responses, which in turn, contribute to the development and progression of CVD. This review summarizes preclinical and clinical evidence on the effects of ethanol in the gut microbiota and discusses the mechanisms by which ethanol-induced gut dysbiosis leads to the activation of the immune system and cardiovascular dysfunction. The crosstalk between ethanol consumption and the gut microbiota and its implications are detailed. In summary, an imbalance in the symbiotic relationship between the host and the commensal microbiota in a holobiont, as seen with ethanol consumption, may contribute to CVD. Therefore, manipulating the gut microbiota, by using antibiotics, probiotics, prebiotics and fecal microbiota transplantation might prove a valuable opportunity to prevent/mitigate the deleterious effects of ethanol and improve cardiovascular health and risk prevention.

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“…The antioxidant effects of other antihypertensive drugs, such as β adrenoceptor blockers 305,404,405 and calcium channel blockers 305,406 have been reported, as well. Hypertension and oxidative stress associated with chronic ethanol intake can be prevented by the β-adrenoceptor blocker, nebivolol 407. Therefore, part of the beneficial effects of some antihypertensive drugs may due to their ability to decrease ROS production.…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms associated with reactive oxygen species and blood pressure regulation

2019

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Hypertension is the most prevalent cause of cardiovascular disease and kidney failure but only about 50% of patients achieve adequate blood pressure control, in part, due to inter-individual genetic variations in the response to antihypertensive medication. Significant strides have been made toward the understanding of the role of reactive oxygen species (ROS) in the regulation of the cardiovascular system. However, the role of ROS in human hypertension is still unclear. Polymorphisms of some genes involved in the regulation of ROS production are associated with hypertension, suggesting their potential influence on blood pressure control and response to antihypertensive medication. This review provides an update on the genes associated with the regulation of ROS production in hypertension and discusses the controversies on the use of antioxidants in the treatment of hypertension, including the antioxidant effects of antihypertensive drugs.

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Nebivolol prevents vascular oxidative stress and hypertension in rats chronically treated with ethanol

Cited by 23 publications

References 47 publications

Protective effects of nebivolol on ovarian ischemia–reperfusion injury in rat

Protective effects of nebivolol on ovarian ischemia–reperfusion injury in rat

Ethanol: striking the cardiovascular system by harming the gut microbiota

Genetic polymorphisms associated with reactive oxygen species and blood pressure regulation

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