Neat synthesis of isothiazole compounds, and studies on their synthetic applications and photophysical properties

Abstract

Ammonium thiocyanate promoted simple, rapid and eco-friendly neat synthesis of isothiazoles has been developed for the first time. It is noteworthy that an instantaneous valuable synthetic route of β-enaminones has...

Recent developments in the solvent-free synthesis of heterocycles

“…Due to the low natural abundance and a variety of applications in pharmaceuticals, isothiozole scaffolds have drawn much attention from synthetic chemists. In 2022, our group first reported a solvent-free methodology (Scheme 22) 35 for the synthesis of isothiozoles 79 by the ammonium thiocyanate-promoted reaction of β-halo vinyl aldehyde 78 . Here, ammonium thiocyanate acts as the source of nitrogen and sulphur.…”

Recent advances in the synthesis of chromenone fused pyrrolo[2,1-a]isoquinoline derivatives

“…These moieties (either natural or synthetic) are significant compounds for their broad spectrum of biological properties, [2][3][4][5][6][7][8][9][10] especially for their anticoagulant, antibacterial, antioxidant, and antiviral as well as anticancer properties reported over the last 150-200 years. Pyrrolo[2,1-a]isoquinoline scaffolds 11 (Fig. 1b) are also important molecules as they are widely distributed in nature.…”

Synthesis of Highly Substituted Pyrrolo[1,2‐a]quinoline‐3,5‐diones through Ag(I) Catalyzed Cyclization of 4‐Hydroxyquinolinyl‐2‐ynones

“…Since biomolecular targets in these cases are different, fusion of quinolone and pyrrolone skeletons with appropriate substitution pattern could help in multi‐targeting, and hence have potential application in anticancer and antibacterial drug discovery efforts. A literature search showed that therapeutic potential of pyrrolo−quinolines, [19–21] indolo−quinolines, [22] isoindolo[2,1‐a]quinoline‐5,11‐diones (eg. II , Figure 1a), [23] and pyrrolo[1,2‐a]quinoline‐1,5‐diones ( III ) [24] have received some attention but pyrrolo[1,2‐a]quinoline‐3,5‐diones of the type I discussed here are yet to undergo detailed investigations, making their synthesis very important.…”