Nearly ten decades of interest in idiopathic pericarditis

Christian, Henry A.

doi:10.1016/0002-8703(51)90169-x

Cited by 38 publications

(6 citation statements)

References 22 publications

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“…Coxsackie virus is the virus most frequently associated with myocarditis (Christian, 1951;Gauntt, 2002;Kim et al, 2001). There are no vaccines or therapeutic reagents in clinical use, although some effective candidates for CVB3 have been suggested in murine models (Gauntt et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of salidrosidein vitroandin vivogenotoxicity

Zhu

Wan

Zhu

et al. 2010

Drug and Chemical Toxicology

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It is reported that salidroside, the main component of a traditional Chinese medicine, Rhodiola rosea, has the efficacy of protecting Coxsackie virus impairment. As part of a safety evaluation on salidroside for use in the treatment of viral myocarditis, the present study evaluated potential genotoxicity of salidroside by using the standard battery of tests (i.e., bacterial reverse mutation assay, chromosomal aberrations assay, and mouse micronucleus assay) recommended by the State Food and Drug Administration of China. The results showed that salidroside was not genotoxic under the conditions of the reverse mutation assay, chromosomal aberrations assay, and mouse micronucleus assay conditions. The anticipated clinical dose seems to be smaller than the doses administered in the genotoxicity assays. With confirmation from further toxicity studies, salidroside would hopefully prove to be a safe anti-Coxsackie virus agent.

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Section: Discussionmentioning

confidence: 99%

Evaluation of salidrosidein vitroandin vivogenotoxicity

Zhu

Wan

Zhu

et al. 2010

Drug and Chemical Toxicology

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“…Myocarditis is an acquired form of inflammatory disease of the heart first described over 150 years ago (1).…”

Section: Causes Of Myocarditismentioning

confidence: 99%

“…There are many infectious agents that can induce myocarditis, including more than a dozen bacterial, protozoal and fungal pathogens and at least 17 viruses (5). Viruses most frequently associated with cases of myocarditis in children and adults in the U.S. and Europe include the enteroviruses and adenoviruses type C (6,7), and to a lesser extent, cytomegalovirus and parvovirus B19 (1,8). Hepatitis C virus has recently been linked to myocarditis and other heart diseases in patients in Japan (9).…”

Section: Causes Of Myocarditismentioning

confidence: 99%

Coxsackievirus experimental heart diseases

Gauntt

Huber²

2003

Front Biosci

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Many microorganisms, particularly viruses, can cause myocarditis, an inflammatory disease of the heart. The frequency of and major factors that contribute to this disease, including a pronounced gender (male) bias, age and genetic background parameters are discussed, along with signs and symptoms of disease in infants to adults. Individuals with acute disease generally recover without sequelae; the chronic form can develop into idiopathic dilated cardiomyopathy and death can follow. Among viruses most frequently associated with cases in the U.S., the coxsackieviruses group B (CVB) are major etiologic agents. The association between the CVB and disease is based on detection of viral RNA in heart biopsy specimens by polymerase chain reaction assays. Excellent CVB-, particularly coxsackievirus B3 (CVB3)-, mouse models of the disease have identified mechanisms of induction and establishment of chronic myocarditis. CVB3-murine models share many biologic parameters of the acute and chronic diseases in humans, and show that cardiopathologic alterations result from virus-induced and immunologic reactions in heart tissues. Several immune responses to a CVB3 infection that become cardiopathogenic, instead of protective, are discussed in an attempt to explain why immunosuppressive treatments are not effective. Bed rest and supportive therapy are the current treatment for patients with myocarditis.

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“…Acute non-specific pericarditis (acute benign pericarditis; acute idiopathic pericarditis) has been recognized for over 100 years (Christian, 1951). In 1942 Barnes & Burchell described fourteen cases of the condition and since then several series of cases have been published (Krook, 1954;Scherl, 1956;Swan, 1960;Martin, 1966;Logue & Wendkos, 1948).…”

Section: Incidencementioning

confidence: 99%

Acute non-specific pericarditis

Gold

1967

Postgraduate Medical Journal

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Nearly ten decades of interest in idiopathic pericarditis

Cited by 38 publications

References 22 publications

Evaluation of salidrosidein vitroandin vivogenotoxicity

Evaluation of salidrosidein vitroandin vivogenotoxicity

Coxsackievirus experimental heart diseases

Acute non-specific pericarditis

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