Processing of gravity and magnetic maps shows that the basement of the Upper Rhine Graben area is characterized by a series of NE-SW trending discontinuities and elongated structures, identified in outcrops in the Vosges, Black Forest, and the Odenwald Mountains. They form a 40 km wide, N30-40°s triking, sinistral wrench-zone that, in the Visean, shifted the Variscan and pre-Variscan structures by at least 43 km to the NE. Wrenching was associated with emplacement of several generations of plutonic bodies emplaced in the time range 340-325 Ma. The subvertical, NE-SW trending discontinuities in the basement acted as zones of weakness, susceptible to reactivation by subsequent tectonism. The first reactivation, marked by mineralizations and palaeomagnetic overprinting along NE-SW faults of the Vosges Mountains, results from the Liassic NW-SE extension contemporaneous with the break-up of Pangea. The major reactivation occurred during the Late Eocene N-S compression and the Early-Middle Oligocene E-W extension. The NE-SW striking basement discontinuities were successively reactivated as sinistral strike-slip faults, and as oblique normal faults. Elongated depocenters appear to form in association with reactivated Variscan wrench faults. Some of the recent earthquakes are located on NE-SW striking Variscan fault zones, and show sinistral strikeslip focal mechanisms with the same direction, suggesting also present reactivation.