We investigate electron-impact single ionization of He-like ions of charge state q = 0,. .. , 6 in the initial ground (1 1 S) and metastable (2 3 S) states. Good agreement between theory and experiment is established for the total cross sections, and then the scaling behavior with q is considered as a function of the ratio u = Ei/EI ≤ 10 of the incident electron energy Ei and the ionization threshold EI. While the expected E 2 I scaling of the cross sections is confirmed, we also find that at each scaled energy u the spin asymmetry (for the 2 3 S state) converges rapidly to a non-zero constant with increasing q. This indicates that, despite EI increasing with q 2 , exchange effects remain undiminished on the broad scaled-energy range considered. We suggest that this physical behavior is more universal than just for the He-like ions.