Near-term prognostic impact of integrated muscle mass and function in upper gastrointestinal cancer

Tang, Meng; Ge, Yi‐Zhong; Zhang, Qi; Zhang, Xi; Xiao, Chunyun; Zhang, Kangping; Song, Mengmeng; Wang, Xin; Yang, Ming; Ruan, Guo‐Tian; Mu, Ying; Huang, Hongyan; Ma, Cong; Zhou, Fen; Shi, Hanping

doi:10.1016/j.clnu.2021.07.028

Cited by 5 publications

(2 citation statements)

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“…In addition, low HGS is recommended as the standard for the definition of cancer cachexia (10). Assessment of HGS provides significant additional prognostic information for patients with cancer, and reduced HGS is considered to be related to deterioration in patient survival (11,12).…”

Section: Introductionmentioning

confidence: 99%

Association of Modified Geriatric Nutrition Risk Index and Handgrip Strength With Survival in Cancer: A Multi-Centre Cohort Study

et al. 2022

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BackgroundThis study aimed to explore the value of combining the modified geriatric nutrition risk index (mGNRI) and handgrip strength (HGS) in the prognosis assessment of cancer.MethodsThis multicenter, prospective cohort study, enrolled 5,607 cancer patients from 27 medical centers across 17 provinces in China between June 2012 and December 2019. The primary outcome was overall survival. Secondary outcomes included the Karnofsky Performance Scale (KPS) score, Patient-Generated Subjective Global Assessment (PG-SGA) score, cachexia, and admission 90-day outcome. A composite prognostic score (mGNRI-HGS score) was developed based on the mGNRI and HGS. The Kaplan–Meier method was used to draw the survival curve, and log-rank analysis was used to estimate the survival rate. The Cox proportional hazards model was used to investigate the associations of the mGNRI, HGS or mGNRI-HGS score with risk of mortality among the cancer patients, adjusted for potential confounders.ResultsA low mGNRI (HR = 0.99, 95%CI = 0.98–0.99, p < 0.001) and low HGS (HR = 0.99, 95%CI = 0.98–0.99, p = 0.001) were associated with an increased risk of mortality. A severe mGNRI-HGS score was independently associated with reduced survival. Compared with patients with normal scores, the risk of mortality among the patients with moderate and severe mGNRI-HGS scores was 28.8 and 13.3% higher, respectively. Even within the same pathological stage, it presented significant gradient prognostic stratification. Additionally, a low mGNRI-HGS score was also independently associated with a higher risk of low KPS (p < 0.001), high PGSGA (p < 0.001), cachexia (p < 0.001), and adverse admission 90-day outcome (p < 0.001).ConclusionsThe mGNRI and HGS may be useful predictors of long-term prognosis in cancer patients. The combination of the two methods provides effective prognostic stratification for cancer patients and could predict physical frailty, malnutrition, and cachexia.

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Section: Introductionmentioning

confidence: 99%

Association of Modified Geriatric Nutrition Risk Index and Handgrip Strength With Survival in Cancer: A Multi-Centre Cohort Study

et al. 2022

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“…Outro estudo envolvendo uma amostra 2.546 pacientes, 527 (20,6%) destes com câncer do trato gastrointestinal superior (72,3% câncer de estômago, 21,8% câncer de pâncreas e 5,9% câncer de esôfago), 65,1% de idade abaixo de 65 anos e estádio II e III como prevalentes na amostra, obteve resultado de baixa massa / função muscular, avaliada pelas medidas de dobra cutânea tricipital, dinamometria e circunferência da panturrilha, em 74,8% dos pacientes. 77 Apesar do estudo de Cresta et al (2019) 78 , Buenos Aires -Argentina, ter sido realizado com 93,0% de pacientes oncológicos metastáticos, a média de força foi de 28,6 Kg, com diferença significativa entre os sexos. Esse valor médio de força foi muito próximo ao obtido no presente estudo (28,4 Kg).…”

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Avaliação de longo prazo do estado nutricional de pacientes tratados com ressecção cirúrgica para câncer de esôfago e estômago

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Calf Circumference and All-Cause Mortality: A Systematic Review and Meta-Analysis Based on Trend Estimation Approaches

Li¹,

Lang²,

Peng

et al. 2022

The Journal of nutrition, health and aging

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Near-term prognostic impact of integrated muscle mass and function in upper gastrointestinal cancer

Cited by 5 publications

References 47 publications

Association of Modified Geriatric Nutrition Risk Index and Handgrip Strength With Survival in Cancer: A Multi-Centre Cohort Study

Association of Modified Geriatric Nutrition Risk Index and Handgrip Strength With Survival in Cancer: A Multi-Centre Cohort Study

Avaliação de longo prazo do estado nutricional de pacientes tratados com ressecção cirúrgica para câncer de esôfago e estômago

Calf Circumference and All-Cause Mortality: A Systematic Review and Meta-Analysis Based on Trend Estimation Approaches

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