Near-infrared upper phenyl-fused BODIPY as a photosensitizer for photothermal–photodynamic therapy

Abstract

BODIPY scaffolds by introducing ring-fused segment promoted bathochromic-shift spectrum and enhanced intersystem crossing capability by a twisted structure. In this work, we designed the upper phenyl-fused BODIPY with 4-dimethylaminostyryl groups...

Research Progress of Photothermal Nanomaterials in Multimodal Tumor Therapy

“…Through chemical modification with a conjugated system, the nano-photosensitizer based on BODIPY has a higher absorption coefficient in the NIR region, which gives it the potential to be used as a PTA ( 215 – 217 ). Yu et al ( 56 ) fabricated an NIR BODIPY dye with an upper phenyl-fused segment (BBDP). The photothermal experimental results demonstrated the PCE of BBDP nanoparticles to be as high as 54.2%, suggesting excellent photothermal capability.…”

Synthesis of aza-BODIPYs with barrier-free rotation of the –tBu group at 3-site and enhancement of photothermal therapy by triggering cancer cell apoptosis

“…In short, tBu-azaBDP 1 exhibited a severely twisted configuration. [35][36][37] Spectroscopic properties of tBu-azaBDPs Firstly, the absorption spectra of tBu-azaBDPs 1, 2 and Ph-azaBDP 3 in CH 2 Cl 2 were investigated. As shown in Fig.…”

Non-aryl substituted aza-BODIPYs at 1,7- or 3,5-sites: synthesis, structures, optical properties, and applications

“…1 Near-infrared (NIR) absorbing aza-BODIPY chromophores have excellent photophysical properties, such as the reduction of background absorption and light scattering, deep penetration in tissues to allow in vivo imaging and photodynamic therapy (PDT), and photothermal therapy (PTT). [2][3][4][5][6][7] Therefore, aza-BODIPYs have been extensively applied in chemical sensors, [8][9][10][11][12] fluorescent dyes, [13][14][15][16][17] laser dyes, [18][19][20] organic photoelectric device, [21][22][23][24][25] dye photosensitizers, [26][27][28][29][30][31][32] photothermal agents, [33][34][35][36][37][38] and other fields. In particular, the NIR chromophores endowed dyes high sensitivity in biological detection with little photodamage to biological tissues and are more suitable for biological diagnosis and phototherapeutics.…”